Correlation between Salivary and Serum CRP Levels in Urticaria Patients

Martina Rahmi, Taufiq Hidayat, Herwinda Brahmanti

2018

Abstract

Urticaria are commonand has a detrimental effect on that adversely impacts the quality of life. Urticaria occurs due to mast cell activation and subsequently followed by inflammatory response. C- reactive protein (CRP), the prototypical acute-phase reactant has been used widely on-specific clinical indicator to assess systemic inflammatory status. Development of salivary CRP assays that is non-invasive, stress- and pain- free may constitute an alternative strategy. To the best knowledge of author, there have been no studies done on the correlation of saliva and serum CRP in urticaria patients. The objective of this study was to find the correlation between salivary and serum CRP levels in patients with urticaria. The study design was cross- sectional observational analytic and 21 urticaria patients were recruited. Saliva and serum CRP levels were measured within 48 hours of lesion onset using immunoturbidimetry and ELISA method. Statistical analysis of the Pearson correlation coefficient was used.Saliva CRP concentrations ranged from 3,00x10 -6 mg/L to 1,77x10 -3 mg/l, mean values were 3,77x10 -4 mg/l (± 4,72x10 -4 ). Serum CRP concentration ranged from 0,40 mg/lto17,40 mg/l, mean values 3,28 mg/l (±3,85). We found a verystrongassociation CRP measured in saliva with serum CRP(r= .814, p <.05). Salivary CRP measurement may thus facilitate alternative method of CRP serum to know inflammatory state in patients with urticaria.

Paper Citation

in Harvard Style

Rahmi M., Hidayat T. and Brahmanti H. (2018). Correlation between Salivary and Serum CRP Levels in Urticaria Patients.In Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD, ISBN 978-989-758-494-7, pages 14-17. DOI: 10.5220/0008149700140017

in Bibtex Style

@conference{rcd18,
author={Martina Rahmi and Taufiq Hidayat and Herwinda Brahmanti},
title={Correlation between Salivary and Serum CRP Levels in Urticaria Patients},
booktitle={Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,},
year={2018},
pages={14-17},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008149700140017},
isbn={978-989-758-494-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,
TI - Correlation between Salivary and Serum CRP Levels in Urticaria Patients
SN - 978-989-758-494-7
AU - Rahmi M.
AU - Hidayat T.
AU - Brahmanti H.
PY - 2018
SP - 14
EP - 17
DO - 10.5220/0008149700140017