A Four Years Retrospective Study of Stevens Johnson Syndrome: Toxic Epidermal Necrolysis Treatments in a National Tertiary Referral Hospital

Sarah Mahri, Teffy Nuary, Fadhli A. Mughni, Windy Keumala B.

2018

Abstract

Stevens-Johnson syndrome (SJS) and/or toxic epidermal necrolysis (TEN) are drug reactions associated to high morbidity and mortality. Prompt diagnosis and management may reduce the mortality rate. The research aims to evaluate the consistency of current treatments for SJS/TEN with the clinical pathway by Dr. Cipto Mangunkusumo National General Hospital and Indonesian Society of Dermatology And Venereology (ISDV). A retrospective review was conducted on patients with SJS/TEN admitted to Dr. Cipto Mangunkusumo National General Hospital, Jakarta during January 2014 to December 2017. The data were collected from paper-based and electronic health medical record database. A total of 34 cases of SJS/TEN were admitted, but only 30 cases with complete data was included, comprising of 20 males and 10 females with the mean age were 37.5 (15-70) years. Carbamazepin was the most common culprit drug. All patients were treated with intravenous methylprednisolone. The average length of stay were 6 days (3-20) in SJS, 8 (3-18) in SJS-TEN, and 11 (4-18) in TEN, while the mortality rate were 18.2% in SJS, 8.3% in SJS- TEN, and 14.3% in TEN. As conclusion, corticosteroids may contribute to reduced mortality rate in SJS/TEN without increasing secondary infection and serious sequele. The current treatments for SJS/TEN in our hospital is consistent with the clinical pathway by Dr. Cipto Mangunkusumo National General Hospital and Indonesian Society of Dermatology And Venereology (ISDV). Further well-designed studies are required to compare the effect of corticosteroids treatment for SJS/TEN to other medications.

Paper Citation

in Harvard Style

Mahri S., Nuary T., Mughni F. and B. W. (2018). A Four Years Retrospective Study of Stevens Johnson Syndrome: Toxic Epidermal Necrolysis Treatments in a National Tertiary Referral Hospital.In Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD, ISBN 978-989-758-494-7, pages 83-87. DOI: 10.5220/0008151300830087

in Bibtex Style

@conference{rcd18,
author={Sarah Mahri and Teffy Nuary and Fadhli A. Mughni and Windy Keumala B.},
title={A Four Years Retrospective Study of Stevens Johnson Syndrome: Toxic Epidermal Necrolysis Treatments in a National Tertiary Referral Hospital},
booktitle={Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,},
year={2018},
pages={83-87},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008151300830087},
isbn={978-989-758-494-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,
TI - A Four Years Retrospective Study of Stevens Johnson Syndrome: Toxic Epidermal Necrolysis Treatments in a National Tertiary Referral Hospital
SN - 978-989-758-494-7
AU - Mahri S.
AU - Nuary T.
AU - Mughni F.
AU - B. W.
PY - 2018
SP - 83
EP - 87
DO - 10.5220/0008151300830087