Correlation between Plasma Level of Superoxide Dismutase and Catalase with the Degree of Severity in Vitiligo

Sudarsa P., Karna R. V., Adiguna M. S.

2018

Abstract

Vitiligo is a common depigmentation disorders of the skin that can affecting all age and genders. This entity has a complex pathogenesis, as one theory emphasize in the role of oxidative stress. Superoxide dismutase (SOD) and catalase are thought as principal enzymatic antioxidant, but increased activity of SOD and lack activity of catalase were thought to play a role in melanocyte damage by accumulation of hydrogen peroxide (H 2 O 2 ). The aim of this study is to assess the correlation between SOD and catalase with the degree of severity in vitiligo patients. This is a cross-sectional study involving 49 patients with vitiligo at Sanglah General Hospital Denpasar Bali in period of August – November 2017. Superoxide dismutase and catalase level were examined in blood plasma to assess its activity whereas degree of severity were determined clinically using scoring system of Vitiligo Area Severity Index (VASI).This study found that the mean of SOD in plasma of vitiligo patients was 0,638 U/ml with the lowest value was 0,49 U/ml and the highest value was 0,75 U/ml. Whereas catalase level was 64,07 U/ml with the lowest value was 55,86 U/ml and the highest was 72,99 U/ml. This study found significant positive correlation (r = 0,473; p < 0,01) between plasma SOD level and VASI score and significant negative correlation (r = - 0,597; p < 0,01) between plasma catalase level and VASI score. Superoxide dismutase catalyzes superoxide anion into oxygen and H 2 O 2 , in which H 2 O 2 subsequently breaks into oxygen and water by the action of catalase. Increased activity of SOD with decreased activity of catalase would lead to accumulation of hydrogen peroxide that could cause melanocyte death that seen clinically as vitiligo.

Paper Citation

in Harvard Style

P. S., R. V. K. and M. S. A. (2018). Correlation between Plasma Level of Superoxide Dismutase and Catalase with the Degree of Severity in Vitiligo.In Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD, ISBN 978-989-758-494-7, pages 92-94. DOI: 10.5220/0008151500920094

in Bibtex Style

@conference{rcd18,
author={Sudarsa P. and Karna R. V. and Adiguna M. S.},
title={Correlation between Plasma Level of Superoxide Dismutase and Catalase with the Degree of Severity in Vitiligo},
booktitle={Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,},
year={2018},
pages={92-94},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008151500920094},
isbn={978-989-758-494-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,
TI - Correlation between Plasma Level of Superoxide Dismutase and Catalase with the Degree of Severity in Vitiligo
SN - 978-989-758-494-7
AU - P. S.
AU - R. V. K.
AU - M. S. A.
PY - 2018
SP - 92
EP - 94
DO - 10.5220/0008151500920094