The Comparison of the Effects of Caffeine Topical 0.25% and 0.5% as Anti-wrinkle Therapy

Susanti Rosmala Dewi, Aris Cahyono, Anggana Rafika P., Prasetyadi Mawardi

2018

Abstract

This 4-weeks, double-blind, randomized, controlled clinical study was conducted to compare the effects of topical caffeine 0.25% with 0.5% on barrier function and elasticity in the skin. A total of 41 healthy subjects consisted of male and female aged 20-60 y.o. The subjects were grouped into two. Each group received a topical caffeine with different concentrations of 0.25% and 0.5%. Hydroxyethylcellulose (HEC) gel as the placebo has 97.5% water content. Physical stability test was conducted at the preparation. The treatment was performed on the forehead and periorbital by applying a topical caffeine 0.25% on one forehead and periorbital and 0.5% on the others. Application of gels was performed 2 times daily for 4 weeks. Measurement of Transepidermal Water Loss (TEWL) using Tewameter® TM300 and elasticity using Elastometer® EM25 were performed before and after treatment. Clinical evaluations for efficacy were made at baseline and after two and 4 weeks of gel use. The measurements results were analyzed using one- way Annova. Overall, the results of the study showed that topical caffeine applications can improve skin barrier function and increase the elasticity the skin especially as anti wrinkle.

Paper Citation

in Harvard Style

Dewi S., Cahyono A., P. A. and Mawardi P. (2018). The Comparison of the Effects of Caffeine Topical 0.25% and 0.5% as Anti-wrinkle Therapy.In Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD, ISBN 978-989-758-494-7, pages 113-117. DOI: 10.5220/0008152001130117

in Bibtex Style

@conference{rcd18,
author={Susanti Rosmala Dewi and Aris Cahyono and Anggana Rafika P. and Prasetyadi Mawardi},
title={The Comparison of the Effects of Caffeine Topical 0.25% and 0.5% as Anti-wrinkle Therapy},
booktitle={Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,},
year={2018},
pages={113-117},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008152001130117},
isbn={978-989-758-494-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,
TI - The Comparison of the Effects of Caffeine Topical 0.25% and 0.5% as Anti-wrinkle Therapy
SN - 978-989-758-494-7
AU - Dewi S.
AU - Cahyono A.
AU - P. A.
AU - Mawardi P.
PY - 2018
SP - 113
EP - 117
DO - 10.5220/0008152001130117