Drug Induced Hypersensitivity Syndrome (DIHS) Patient Characteristics in Dermatology and Venereology Department, Dr. Cipto Mangunkusumo National General Hospital in the Period 2014 to 2017

Teffy Nuary, Sarah Mahri, Windy Keumala B.

2018

Abstract

Drug induced hypersensitivity syndrome (DIHS) is a distinct, severe, idiosyncratic reaction to a drug characterized by a prolonged latency period with cutaneous presentation and internal organ involvement. In Asia, DIHS was reported to almost one tenth of adverse drug reaction cases, with a mortality rate ranged 3- 10%. The aim of this study are to describe the sociodemographic and clinical characteristics of patients with DIHS and causative agents in Dermatology and Venereology Department Dr. Cipto Mangunkusumo National General Hospital, Jakarta. This study is a descriptive study. Using medical records and electronic health record of patients with DIHS were retrospectively reviewed. During 2014-2017 we identified 18 female, 14 male patients, with age range 14-87 years. Onset of the disease since exposed by culprit drugs were 14-40 days.The most common underlying disease was accute infection disease (43,7%). The DIHS clinical features and laboratory finding in this study are fever (93,7%), maculopapular rash (90,6%), target lesions (12,5 %), facial oedema (21,5%), periorbital oedema (12,5%). lymph nodes enlargement (93,7%), eosinofilia (31,2 %) , elevating of liver function (100%), and one patients (3,1%) showed kidney involvement .The most common causative drugs were antibacterials (60 %). all patients, the causative drug was discontinued and treated with systemic corticosteroids. As the conclusion DIHS is a severe drug hypersensitivity reaction with prominent cutaneous and systemic manifestations. Dispite the limitations, this study present some variations of DIHS clinical features and many other drugs that implicated.

Paper Citation

in Harvard Style

Nuary T., Mahri S. and B. W. (2018). Drug Induced Hypersensitivity Syndrome (DIHS) Patient Characteristics in Dermatology and Venereology Department, Dr. Cipto Mangunkusumo National General Hospital in the Period 2014 to 2017.In Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD, ISBN 978-989-758-494-7, pages 127-131. DOI: 10.5220/0008152301270131

in Bibtex Style

@conference{rcd18,
author={Teffy Nuary and Sarah Mahri and Windy Keumala B.},
title={Drug Induced Hypersensitivity Syndrome (DIHS) Patient Characteristics in Dermatology and Venereology Department, Dr. Cipto Mangunkusumo National General Hospital in the Period 2014 to 2017},
booktitle={Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,},
year={2018},
pages={127-131},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008152301270131},
isbn={978-989-758-494-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,
TI - Drug Induced Hypersensitivity Syndrome (DIHS) Patient Characteristics in Dermatology and Venereology Department, Dr. Cipto Mangunkusumo National General Hospital in the Period 2014 to 2017
SN - 978-989-758-494-7
AU - Nuary T.
AU - Mahri S.
AU - B. W.
PY - 2018
SP - 127
EP - 131
DO - 10.5220/0008152301270131