Difference of Histamine Expression between Multibacillary Leprosy with and without Erythema Nodosum Leprosum (ENL) Reaction

Dwi Septiana, Puguh Riyanto, Asih Budiastuti, Dhiana Ernawati, Soejoto , E. S. Indrayanti

2018

Abstract

Leprosy is a chronic infectious disease that poses a problem for public health because it causes disability. One of the causes for this disability is leprosy reaction. Erythema Nodosum Leprosum (ENL) is a type 2 leprosy reactions, which were more frequent in borderline lepromatous (BL), and lepromatous (LL) type of leprosy receiving multi drug therapy (MDT) for multibacillary leprosy (MB). Histamine, primarily H4 receptor- mediated, plays role in inflammation by increasing vascular permeability and muscle contraction resulting in leukocytes migration and leakage of plasma containing antibodies and tissue complements. This cascade finally results in tissue inflammation. To our knowledge, there is no previous study analysing histamine expression difference between MB leprosy with and without ENL reaction. The purpose of the research was to understand the difference of histamine expression in MB leprosy patients with and without ENL reactions who received MDT for at least 6 months. The method of the research was an observational study with cross-sectional approach. Study samples were 32 people divided into 2 groups, 16 samples in without ENL reactions group and 16 samples in with ENL reactions group. Histamine expression was measured based on Allred scoring system. The result from Difference test for histamine expression between two study groups using Mann Whitney Test showed p < 0.05 (p=0.030 ). The study found that mean histamine expression of ENL MB patients was higher than non-ENL MB patients.

Paper Citation

in Harvard Style

Septiana D., Riyanto P., Budiastuti A., Ernawati D., S. and Indrayanti E. (2018). Difference of Histamine Expression between Multibacillary Leprosy with and without Erythema Nodosum Leprosum (ENL) Reaction.In Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD, ISBN 978-989-758-494-7, pages 159-162. DOI: 10.5220/0008153001590162

in Bibtex Style

@conference{rcd18,
author={Dwi Septiana and Puguh Riyanto and Asih Budiastuti and Dhiana Ernawati and Soejoto and E. S. Indrayanti},
title={Difference of Histamine Expression between Multibacillary Leprosy with and without Erythema Nodosum Leprosum (ENL) Reaction},
booktitle={Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,},
year={2018},
pages={159-162},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008153001590162},
isbn={978-989-758-494-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,
TI - Difference of Histamine Expression between Multibacillary Leprosy with and without Erythema Nodosum Leprosum (ENL) Reaction
SN - 978-989-758-494-7
AU - Septiana D.
AU - Riyanto P.
AU - Budiastuti A.
AU - Ernawati D.
AU - S.
AU - Indrayanti E.
PY - 2018
SP - 159
EP - 162
DO - 10.5220/0008153001590162