Comparison of Minimal Inhibitory Concentration Level in Vitro of Itraconazole and Fluconazole against Malassezia furfur in Patients with Pityriasis vesicolor in Makasar

Dian Anggraeni, Olivia Wibisono, Safruddin Amin, Andi Muhammad Adam, Khairuddin Djawad

2018

Abstract

Pityriasis Versicolor (PV), the second most common dermatomycosis in Indonesia, is a superficial fungal infection that is frequently reported in the tropics with warm temperatures and high humidity, as in Makassar. Recurrence and long course of disease in PV is most often caused by M. furfur species. Hence, oral antifungal is commonly used in extensive, recalcitrant and recurrent infections. The aim of this study is to assess the MIC of Itraconazole (ITC) and Fluconazole (FLC) against M. furfur of PV patients in Makassar. This is a multi-center cross sectional observational study with consecutive sampling of 21 isolates from PV patients in Makassar, with the identification of M. furfur from morphological (culture using modified Dixon agar) and biochemical criteria (catalase test and lipid assimilation test using Tween- 20, 40, 60, 80, Cremophor El). Our study shows MIC for ITC and FLC against M. furfur ranged from <0.03-0.25 μg/mL and <0.03-2 μg/mL, respectively with MIC of ITC is lower than FLC. The regimen of ITC as systemic antifungal therapy for PV patients in Makassar, particularly caused by M. furfur might be a more effective option.

Paper Citation

in Harvard Style

Anggraeni D., Wibisono O., Amin S., Adam A. and Djawad K. (2018). Comparison of Minimal Inhibitory Concentration Level in Vitro of Itraconazole and Fluconazole against Malassezia furfur in Patients with Pityriasis vesicolor in Makasar.In Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD, ISBN 978-989-758-494-7, pages 163-166. DOI: 10.5220/0008153101630166

in Bibtex Style

@conference{rcd18,
author={Dian Anggraeni and Olivia Wibisono and Safruddin Amin and Andi Muhammad Adam and Khairuddin Djawad},
title={Comparison of Minimal Inhibitory Concentration Level in Vitro of Itraconazole and Fluconazole against Malassezia furfur in Patients with Pityriasis vesicolor in Makasar},
booktitle={Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,},
year={2018},
pages={163-166},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008153101630166},
isbn={978-989-758-494-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,
TI - Comparison of Minimal Inhibitory Concentration Level in Vitro of Itraconazole and Fluconazole against Malassezia furfur in Patients with Pityriasis vesicolor in Makasar
SN - 978-989-758-494-7
AU - Anggraeni D.
AU - Wibisono O.
AU - Amin S.
AU - Adam A.
AU - Djawad K.
PY - 2018
SP - 163
EP - 166
DO - 10.5220/0008153101630166