Clinical and Life Quality Improvement, and IL-17 Serum Level in Psoriasis Patients Treated with Metothrexate Injection: A Pilot Study in 15 Severe Psoriasis Cases

Prasta Bayu Putra, Kusnindita Noria Rahmawati, Adissa Tiara Yulinvia, Sunardi Radiono, Dyah Ayu Mira Oktarina

2018

Abstract

Psoriasis is an autoimmune T cell mediated chronic skin disorder which is difficult to treat. Conventional therapy using oral methotrexate in severe cases often showed unsatisfying result. Our department was developing methotrexate injection protocol for severe cases to improve patient treatment and life quality and for achieving quick remission. Objective: This pilot study was aimed to observe efficacy of methotrexate injection 50mg/week for 6 consecutive weeks. Method: Study subjects were severe psoriasis patients that unresponsive to any conventional therapies. PASI score and DLQI score improvement and serum IL-17 level at the end of study were measured. Result: PASI-100 was achieved by 12 subjects (80%) at the end of sixth weeks. DLQI score were significantly different (p<0.001) after sixth injection and subjects serum IL-17 level were not significantly different with healthy peoples at the end of study. Conclusion: Methotrexate injection 50mg/week for 6 consecutive weeks initiation can be considered as an effective treatment for severe psoriasis. Further studies with larger samples and longer observation period are needed to determine long term efficacy, side effects, and protocol guideline policy.

Paper Citation

in Harvard Style

Putra P., Rahmawati K., Yulinvia A., Radiono S. and Oktarina D. (2018). Clinical and Life Quality Improvement, and IL-17 Serum Level in Psoriasis Patients Treated with Metothrexate Injection: A Pilot Study in 15 Severe Psoriasis Cases.In Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD, ISBN 978-989-758-494-7, pages 176-180. DOI: 10.5220/0008153401760180

in Bibtex Style

@conference{rcd18,
author={Prasta Bayu Putra and Kusnindita Noria Rahmawati and Adissa Tiara Yulinvia and Sunardi Radiono and Dyah Ayu Mira Oktarina},
title={Clinical and Life Quality Improvement, and IL-17 Serum Level in Psoriasis Patients Treated with Metothrexate Injection: A Pilot Study in 15 Severe Psoriasis Cases},
booktitle={Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,},
year={2018},
pages={176-180},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008153401760180},
isbn={978-989-758-494-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,
TI - Clinical and Life Quality Improvement, and IL-17 Serum Level in Psoriasis Patients Treated with Metothrexate Injection: A Pilot Study in 15 Severe Psoriasis Cases
SN - 978-989-758-494-7
AU - Putra P.
AU - Rahmawati K.
AU - Yulinvia A.
AU - Radiono S.
AU - Oktarina D.
PY - 2018
SP - 176
EP - 180
DO - 10.5220/0008153401760180