Adverse Cutaneous Drug Reactions Due to Antituberculosis Therapy in Dr. Sardjito General Hospital Yogyakarta

Kusnindita Noria Rahmawati, Danar Wicaksono, Fajar Waskito, Sri Awalia Febriana

2018

Abstract

Tuberculosis (TB) is a major health problem worldwide. From 2014-2017, 577 cases of TB were recorded in Dr. Sardjito Hospital Yogyakarta. Use of specific agents against Mycobacterium tuberculosis is mainstay of TB treatment. First line anti-TB therapy used are rifampicin, isoniazid, pyrazinamide, and ethambutol. This regimen can cause various adverse drug reaction affecting several organs, including skin. Presence of adverse cutaneous drug reactions (ACDRs) to anti-TB therapy can reduce the effectiveness of therapy and increase the morbidity and mortality of TB patients. This study aimed to understand the type of ACDRs that frequently occur due to anti-TB therapy, the most common causative drugs, and to describe the clinical characteristics including the patch test results. This is a retrospective cross-sectional study on TB patients receiving anti-TB therapy in Dr. Sardjito General Hospital Yogyakarta from 2014-2017. Medical record investigation was conducted to find cutaneous reactions appeared during the course of anti-TB therapy. There were 33 out of 577 patients recorded with ACDRs, maculopapular rash was the most common type (66.7%), followed with Stevens Johnson-Syndrome (12%); Drug Reaction Eosinophilia & Systemic Symptoms (DRESS) (6%) and acneiform eruption (6%); erythroderma(3%), exfoliative dermatitis(3%), and bullous drug eruption (3%). Fifteen out of 33 patients had underwent patch tests examination. Rifampicin was found to be the most causative agent, followed by pyrazinamide, ethambutol and isoniazide. As conclusion, maculopapular rash is the most frequent anti-TB therapy-related ACDRs with rifampicin as the most frequent causative drug based on patch test results in Dr. Sardjito General Hospital Yogyakarta.

Paper Citation

in Harvard Style

Rahmawati K., Wicaksono D., Waskito F. and Febriana S. (2018). Adverse Cutaneous Drug Reactions Due to Antituberculosis Therapy in Dr. Sardjito General Hospital Yogyakarta.In Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD, ISBN 978-989-758-494-7, pages 186-189. DOI: 10.5220/0008153601860189

in Bibtex Style

@conference{rcd18,
author={Kusnindita Noria Rahmawati and Danar Wicaksono and Fajar Waskito and Sri Awalia Febriana},
title={Adverse Cutaneous Drug Reactions Due to Antituberculosis Therapy in Dr. Sardjito General Hospital Yogyakarta},
booktitle={Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,},
year={2018},
pages={186-189},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008153601860189},
isbn={978-989-758-494-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,
TI - Adverse Cutaneous Drug Reactions Due to Antituberculosis Therapy in Dr. Sardjito General Hospital Yogyakarta
SN - 978-989-758-494-7
AU - Rahmawati K.
AU - Wicaksono D.
AU - Waskito F.
AU - Febriana S.
PY - 2018
SP - 186
EP - 189
DO - 10.5220/0008153601860189