A New Insight on Atopic Skin Diathesis: Is It Correlated with the Severity of Melasma

Danar Wicaksono, Rima Mustafa, Sri Awalia Febriana, Kristiana Etnawati

2018

Abstract

Melasma is a macular lesion of light brown to dark on the sun-exposed area, especially on the face. Atopic Skin Diathesis (ASD) is a clinical term to describe skin atopics with previous, present or future atopic dermatitis (AD). Dennie-Morgan infraorbital folds are secondary creases in the skin below the lower eyelids with a sensitivity of 78% and a specificity of 76% to diagnose AD. Melasma skin is characterized by impaired stratum corneum integrity and a delayed barrier recovery rate. Barrier dysfunction will stimulate keratinocyte to secrete keratinocyte-derived factor, which plays role in skin pigmentation process in melasma. To analyze correlation between ASD and Melasma Area Severity Index (MASI) score in melasma patient. This study is an observational analytic study with cross sectional design. Measurement of ASD and MASI score were done in 60 subjects with melasma who went to dermatology outpatient clinic Dr. Sardjito General Hospital from July 2017 to Januari 2018. The correlation between ASD and MASI score was analyzed using Pearson correlation. The result of this study showed no significant correlation between ASD and MASI scores (r: 0.02, p: 0,85). Crude Relative Risk (RR) for Dennie-Morgan infraorbital folds and MASI score was 4 (1.01-15.87). There was no correlation between ASD and MASI scores. Patient with Dennie-Morgan infraorbital folds has 4 times higher risk for developing severe melasma.

Paper Citation

in Harvard Style

Wicaksono D., Mustafa R., Febriana S. and Etnawati K. (2018). A New Insight on Atopic Skin Diathesis: Is It Correlated with the Severity of Melasma.In Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD, ISBN 978-989-758-494-7, pages 190-194. DOI: 10.5220/0008153701900194

in Bibtex Style

@conference{rcd18,
author={Danar Wicaksono and Rima Mustafa and Sri Awalia Febriana and Kristiana Etnawati},
title={A New Insight on Atopic Skin Diathesis: Is It Correlated with the Severity of Melasma},
booktitle={Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,},
year={2018},
pages={190-194},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008153701900194},
isbn={978-989-758-494-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,
TI - A New Insight on Atopic Skin Diathesis: Is It Correlated with the Severity of Melasma
SN - 978-989-758-494-7
AU - Wicaksono D.
AU - Mustafa R.
AU - Febriana S.
AU - Etnawati K.
PY - 2018
SP - 190
EP - 194
DO - 10.5220/0008153701900194