The Effectiveness of Rifampicin, Ofloxacin, and Clarithromycin Combination Therapy in Multibacillary Leprosy Patients

Huany Wongdjaja, Irwan Junawanto, H. A. M. Adam, Farida Tabri, Muhlis

2018

Abstract

The aim of this research is to evaluate the effectiveness of rifampicin, ofloxacin, and clarithromycin (ROC) combination therapy in the treatment of multibacillary leprosy by comparing it with the multi drug therapy (MDT) for multibacillary leprosy (MB) recommended by WHO. This double-blinded RCT was done in 26 previously-untreated MB leprosy patients who were given 600 mg rifampicin, 400 mg ofloxacin, and 500 mg clarithromycin combination therapy for 12 weeks (n=13) and MDT regimen (n=13). Clinical improvement, acid fast bacilli examination, and histopathological examination were assessed before and after the 12-week treatment period. This study showed that the group treated with ROC combination therapy showed superior bacteriological and histopathological improvement compared to the MDT group. The ROC regimen is a potential alternative regimen for MB leprosy patients, especially those who experienced relapse or are uncompliant.

Paper Citation

in Harvard Style

Wongdjaja H., Junawanto I., Adam H., Tabri F. and Muhlis. (2018). The Effectiveness of Rifampicin, Ofloxacin, and Clarithromycin Combination Therapy in Multibacillary Leprosy Patients.In Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD, ISBN 978-989-758-494-7, pages 209-213. DOI: 10.5220/0008154102090213

in Bibtex Style

@conference{rcd18,
author={Huany Wongdjaja and Irwan Junawanto and H. A. M. Adam and Farida Tabri and Muhlis},
title={The Effectiveness of Rifampicin, Ofloxacin, and Clarithromycin Combination Therapy in Multibacillary Leprosy Patients},
booktitle={Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,},
year={2018},
pages={209-213},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008154102090213},
isbn={978-989-758-494-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,
TI - The Effectiveness of Rifampicin, Ofloxacin, and Clarithromycin Combination Therapy in Multibacillary Leprosy Patients
SN - 978-989-758-494-7
AU - Wongdjaja H.
AU - Junawanto I.
AU - Adam H.
AU - Tabri F.
AU - Muhlis.
PY - 2018
SP - 209
EP - 213
DO - 10.5220/0008154102090213