Effect of Vitamin D Supplementation on Changes in the Severity of the Clinical Symptoms of Atopic Dermatitis

Nanda Earlia, Mimi Maulida, Vella, Rovy Pratama

2018

Abstract

Background: Vitamin D is a fat-soluble vitamin primarily produced by the skin, and it plays a role in innate and adaptive immune system regulation mechanisms. Vitamin D is also associated with the production of antimicrobial peptide by keratinocytes, which are potentially used for the management of atopic dermatitis, psoriasis, vitiligo, acne and rosacea. Objective: To evaluate the effect of vitamin D supplementation on changes in the severity of atopic dermatitis. Methods: This study is a double-blind clinical trial study with a parallel design. A total of 56 subjects were divided into two groups: a group that received vitamin D supplementation of 600 IU daily for 28 days (treatment group) and a group that did not receive vitamin D supplementation (control group). Both groups received standard therapy in the form of antihistamines, topical corticosteroids and moisturisers. The degree of severity of the clinical symptoms of atopic dermatitis was measured using Scoring Atopic Dermatitis index. Data analysis was conducted by using a general test linear model with a 95% confidence level. Results: The mean age of the treatment and the control group was9.5 ± 4.3 years and 7.4 ± 5.1 years, respectively. In the admissions group, the mean of 31.9 ± 9.8 improved to 12.8 ± 6.2 after 28 days of study. Similar to the treatment group, the average of the control group changed from 28.8 ± 15.1 to 13.9 ± 7.8. The result of the data analysis showed no significant difference in the degree of clinical symptom between the treatment group and the control group because the p value was equal to 0.165. Conclusion: Vitamin D supplementation of 600 IU in children for 28 days was not effective in reducing the severity of atopic dermatitis.

Paper Citation

in Harvard Style

Earlia N., Maulida M., Vella. and Pratama R. (2018). Effect of Vitamin D Supplementation on Changes in the Severity of the Clinical Symptoms of Atopic Dermatitis.In Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD, ISBN 978-989-758-494-7, pages 219-222. DOI: 10.5220/0008154302190222

in Bibtex Style

@conference{rcd18,
author={Nanda Earlia and Mimi Maulida and Vella and Rovy Pratama},
title={Effect of Vitamin D Supplementation on Changes in the Severity of the Clinical Symptoms of Atopic Dermatitis},
booktitle={Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,},
year={2018},
pages={219-222},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008154302190222},
isbn={978-989-758-494-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,
TI - Effect of Vitamin D Supplementation on Changes in the Severity of the Clinical Symptoms of Atopic Dermatitis
SN - 978-989-758-494-7
AU - Earlia N.
AU - Maulida M.
AU - Vella.
AU - Pratama R.
PY - 2018
SP - 219
EP - 222
DO - 10.5220/0008154302190222