Ki-67 Staining as a Tool to Differentiate Verrucous Carcinoma from Condyloma Acuminatum on Skin Biopsy

Willy Sandhika

2018

Abstract

Verrucous carcinoma is a variant of well differentiated squamous cell carcinoma that slowly growing and rarely metastasize. It grows as polypoid mass with verrucous surface. Macroscopically can produce exophytic appearance that mimic condyloma acuminatum. On skin biopsy specimen that usually tiny tissue, the microscopic appearance can be similar with condyloma acuminatum because it composed of well differentiated squamous epithelial cells. Ki-67 staining can label proliferating cell even they are not in mitotic state. Verrucous carcinoma has high proliferation index while condyloma acuminatum has low index. This study want to prove whether Ki-67 staining can serve as reliable marker to differentiated verrucous carcinoma from condyloma acuminatum. Sixteen case are retrieve from archive of Pathologic Department Dr, Soetomo Hospital consist eight case verrucous carcinoma and condyloma acuminatum respectively. Immunohistochemical staining with antibody Ki-67 was performed on each case. Squamous epithelial cells that stain positive were count from each case, and the results were statistically compare between verrucous carcinoma and condyloma acuminatum. The result of this study shows significant difference in number of Ki-67 positive cells in verrucous carcinoma compare to condyloma acuminatum. There is also different in squamous cell layer that expressed Ki-67. It is concluded that Ki-67 staining is a reliable tool that can differentiate verrucous carcinoma from condyloma acuminatum on skin biopsy specimen.

Paper Citation

in Harvard Style

Sandhika W. (2018). Ki-67 Staining as a Tool to Differentiate Verrucous Carcinoma from Condyloma Acuminatum on Skin Biopsy.In Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD, ISBN 978-989-758-494-7, pages 299-301. DOI: 10.5220/0008156102990301

in Bibtex Style

@conference{rcd18,
author={Willy Sandhika},
title={Ki-67 Staining as a Tool to Differentiate Verrucous Carcinoma from Condyloma Acuminatum on Skin Biopsy},
booktitle={Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,},
year={2018},
pages={299-301},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008156102990301},
isbn={978-989-758-494-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,
TI - Ki-67 Staining as a Tool to Differentiate Verrucous Carcinoma from Condyloma Acuminatum on Skin Biopsy
SN - 978-989-758-494-7
AU - Sandhika W.
PY - 2018
SP - 299
EP - 301
DO - 10.5220/0008156102990301