Hand-foot Syndrome Due to Capecitabine: Report of Two Cases

Marsha Bianti, Aninda Marina, Wresti Indriatmi, Sandra Widaty

2018

Abstract

Capecitabine is one of the most common chemotherapy drugs known to cause hand-foot syndrome (HFS). It is indicated as adjuvant therapy for the treatment of colorectal cancer, first-line therapy in metastatic colorectal cancer, and as monotherapy or in combination with docetaxel in metastatic breast cancer. Although considered to be safe, it has some adverse effect, such as HFS, which is a localized skin eruption associated with the initiation of therapy with certain chemotherapeutic agents. It is considered common and mild thus frequently but improperly self-managed and impaired quality of life. A fifty seven years old woman on treatment with capecitabine for breast cancer and a 46-years-old woman on treatment with capecitabine for breast and thyroid cancer presented with dry and fissured skin on both palms and soles. They also noted pain and discomfort while doing their daily activities. On examination, there were multiple erythematous-hyperpigmented plaques, with scales and fissures overlying it on both palms and soles. Both patients were diagnosed with hand-foot syndrome due to capecitabine and responded well to topical emollients and steroid

Paper Citation

in Harvard Style

Bianti M., Marina A., Indriatmi W. and Widaty S. (2018). Hand-foot Syndrome Due to Capecitabine: Report of Two Cases.In Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD, ISBN 978-989-758-494-7, pages 415-419. DOI: 10.5220/0008158704150419

in Bibtex Style

@conference{rcd18,
author={Marsha Bianti and Aninda Marina and Wresti Indriatmi and Sandra Widaty},
title={Hand-foot Syndrome Due to Capecitabine: Report of Two Cases},
booktitle={Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,},
year={2018},
pages={415-419},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008158704150419},
isbn={978-989-758-494-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,
TI - Hand-foot Syndrome Due to Capecitabine: Report of Two Cases
SN - 978-989-758-494-7
AU - Bianti M.
AU - Marina A.
AU - Indriatmi W.
AU - Widaty S.
PY - 2018
SP - 415
EP - 419
DO - 10.5220/0008158704150419