Hemorrhagic Varicella in Osteosarcoma: Case Report Is It Induced by Chemotherapy Agent or Nature of the Disease?

Benny Nelson, Matahari Arsy Harum P., Vita Siphra, Eliza Miranda, Sri Linuwih Menaldi

2018

Abstract

Varicella is a result of primary varicella-zoster virus infection and can be found worldwide. Eventhough varicella is a self-limiting disease, serious complications can occur in 2-6% cases, especially in neonatus, adults, and immunocompromised patients. The uncommon hemorrhagic complication that occurs in these patients could be the result of thrombocytopenia, increased capillary pressure secondary to cutaneous hyperemia, or bacterial secondary infection. Thrombocytopenia state can be caused by the chemotherapy agent and be worsen by the increasing antibody response to the platelets, interaction between the virus and the platelets resulting early removal of platelets by the reticuloendothelial system, or the release of the neuraminidase from the virus. Mortality rates of complicated varicella is 63%. We report 2 patients with hemorrhagic varicela in osteosarcoma in the facial region and thrombocytopenia. Both patients were clinically diagnosed with varicella and were given intravenous acyclovir 10 mg / kg bodyweight for 10 consecutive days. During treatment, there were no new vesicles, last crop of vesicles had crusted. Thrombocytopenia state was corrected with thrombocyte concentrate (TC) transfusion and fortunately no internal bleeding found.

Paper Citation

in Harvard Style

Nelson B., Harum P. M., Siphra V., Miranda E. and Menaldi S. (2018). Hemorrhagic Varicella in Osteosarcoma: Case Report Is It Induced by Chemotherapy Agent or Nature of the Disease?.In Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD, ISBN 978-989-758-494-7, pages 420-423. DOI: 10.5220/0008158804200423

in Bibtex Style

@conference{rcd18,
author={Benny Nelson and Matahari Arsy Harum P. and Vita Siphra and Eliza Miranda and Sri Linuwih Menaldi},
title={Hemorrhagic Varicella in Osteosarcoma: Case Report Is It Induced by Chemotherapy Agent or Nature of the Disease?},
booktitle={Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,},
year={2018},
pages={420-423},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008158804200423},
isbn={978-989-758-494-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,
TI - Hemorrhagic Varicella in Osteosarcoma: Case Report Is It Induced by Chemotherapy Agent or Nature of the Disease?
SN - 978-989-758-494-7
AU - Nelson B.
AU - Harum P. M.
AU - Siphra V.
AU - Miranda E.
AU - Menaldi S.
PY - 2018
SP - 420
EP - 423
DO - 10.5220/0008158804200423