The Efficacy of Platelet-rich Plasma Combined with Platelet-rich Fibrin in the Treatment of Multiple Chronic Venous Leg Ulcer: A Case Report

Primadhanty Bhadra, Indah Julianto, Mardiana, Adniana Nareswari, Halim Perdana, Endra Yustin Ellista Sari

2018

Abstract

Chronic leg ulcer (CLU) is a defect in the skin below of knee persisting for more than six weeks and shows no tendency to heal after three or more months. Leg ulcers occur in 1% of the adult population and 3.6% in people over 65 years. It may increase with the onset of aging, people with atherosclerotic occlusion such as smoker, obese and diabetic. A 55 years old woman, came with multiple ulcer in her left leg since 5 years ago. There were various size of ulcers in her left leg, the largest size was 12x 9x 0. 1 cm and the smallest one was 6x 6x 0. 1 cm with erythema base. On examination ankle brachial index (ABI) was 0. 9. Patient was diagnosed with deep vein thrombosis (DVT) since 5 years ago, with no satisfying treatment. Compression therapy is still the basic treatment for venous ulcers, but in our case, compression therapy was not given satisfactory result. Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) autologous are some of the therapies that we can use in chronic wounds. Autologous PRP and PRF are contain many growth factors (GF), that can help the healing process in chronic wounds, the treatments are easy to use, painless and safe. In our case we used combined therapy of PRP and PRF for treating CLU and we also used intralesional PRP injection for the initial treatment and results in satisfying improvement after 13 weeks observation.

Paper Citation

in Harvard Style

Bhadra P., Julianto I., Mardiana., Nareswari A., Perdana H. and Sari E. (2018). The Efficacy of Platelet-rich Plasma Combined with Platelet-rich Fibrin in the Treatment of Multiple Chronic Venous Leg Ulcer: A Case Report.In Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD, ISBN 978-989-758-494-7, pages 510-513. DOI: 10.5220/0008160905100513

in Bibtex Style

@conference{rcd18,
author={Primadhanty Bhadra and Indah Julianto and Mardiana and Adniana Nareswari and Halim Perdana and Endra Yustin Ellista Sari},
title={The Efficacy of Platelet-rich Plasma Combined with Platelet-rich Fibrin in the Treatment of Multiple Chronic Venous Leg Ulcer: A Case Report},
booktitle={Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,},
year={2018},
pages={510-513},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008160905100513},
isbn={978-989-758-494-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,
TI - The Efficacy of Platelet-rich Plasma Combined with Platelet-rich Fibrin in the Treatment of Multiple Chronic Venous Leg Ulcer: A Case Report
SN - 978-989-758-494-7
AU - Bhadra P.
AU - Julianto I.
AU - Mardiana.
AU - Nareswari A.
AU - Perdana H.
AU - Sari E.
PY - 2018
SP - 510
EP - 513
DO - 10.5220/0008160905100513