Combination of Intravenous Methylprednisolone and Cyclophosphamide Pulse Therapy Weekly in Severe Autoimmune Bullous Disease: A Preliminary Report

Jesslyn Amelia, Prasta Putra, Yohanes Wirohadidjojo, Sunardi Radiono

2018

Abstract

Pemphigus vulgaris (PV), pemphigus foliaceus (PF), and bullous pemphigoid (BP) are amongst autoimmune bullous skin diseases that are characterized by bullae formation at different levels of the skin. The mainstay treatment is still by systemic corticosteroids, but the outcome is not satisfying with many side effects and frequent relapse. One of the drugs that can be used as steroid-sparing agent is cyclophosphamide. In this report, we evaluate the therapy outcome of intravenous methylprednisolone and cyclophosphamide pulsed therapy (MCP) weekly in 6 patients with severe PV, PF, and BP who have completed six MCP. The severity of the disease was measured using Pemphigus Disease Area Index (PDAI) for pemphigus and Bullous Pemphigoid Disease Area Index (PBDAI) for bullous pemphigoid. The aim of this report is to evaluate the therapy response and the side effects of this regimen therapy. After being given six MCP, four patients showed excellent response therapy, one patient showed a good response therapy, while one patient showed a poor response therapy. MCP might be an effective treatment for severe pemphigus and BP but the side effects should be closely monitored. Further long follow up is needed to see the possibilities of relapse and the safety of this regimen therapy to be used in larger sample population.

Paper Citation

in Harvard Style

Amelia J., Putra P., Wirohadidjojo Y. and Radiono S. (2018). Combination of Intravenous Methylprednisolone and Cyclophosphamide Pulse Therapy Weekly in Severe Autoimmune Bullous Disease: A Preliminary Report.In Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD, ISBN 978-989-758-494-7, pages 514-518. DOI: 10.5220/0008161005140518

in Bibtex Style

@conference{rcd18,
author={Jesslyn Amelia and Prasta Putra and Yohanes Wirohadidjojo and Sunardi Radiono},
title={Combination of Intravenous Methylprednisolone and Cyclophosphamide Pulse Therapy Weekly in Severe Autoimmune Bullous Disease: A Preliminary Report},
booktitle={Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,},
year={2018},
pages={514-518},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008161005140518},
isbn={978-989-758-494-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,
TI - Combination of Intravenous Methylprednisolone and Cyclophosphamide Pulse Therapy Weekly in Severe Autoimmune Bullous Disease: A Preliminary Report
SN - 978-989-758-494-7
AU - Amelia J.
AU - Putra P.
AU - Wirohadidjojo Y.
AU - Radiono S.
PY - 2018
SP - 514
EP - 518
DO - 10.5220/0008161005140518