The Preservation of Liposomes During Air Drying Using a Matrix Containing Maltodextrin and HPMC

Raditya Weka Nugraheni, Helmy Yusuf, Dwi Setyawan

2018

Abstract

This study used maltodextrin as a protectant to stabilize liposomes during air drying and Hydroxypropyl Methyl Cellulose (HPMC) as solid dispersion matrix that could provide a barrier to the coalescence of liposomes. The purpose was to optimize the composition of the matrix to protect liposomes. The liposome suspension was prepared with the thin-film hydration method using three lipid components with the molar ratio of SPC:DDA:Chol = 9:3:1. The maltodextrin was dissolved in water and used in the experiment as the hydration liquid. The formulations included maltodextrin and HPMC with 4 (four) different ratios. Then, they were air-dried at the same condition (40ºC for 120 hours). The solid products were characterized using Powder X-Ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC), and Scanning Electron Microscopy (SEM). The PXRD analysis showed that all of the formulations developed in this study had an amorphous structure. However, the formulations showed peak splitting in the DSC analysis. The differences in the crystalline lamellar thickness of maltodextrin might be the cause of these results during the air drying. The successful preservation of liposomes was analyzed using SEM photomicrography. Compared with the other formulations, F2MO3 created the best protection for liposomes. The inclusion of HPMC as a dispersion matrix into the liposome formulation potentially inhibits crystal formation during the drying process and, therefore, provides better protection for the lipid bilayer.

Paper Citation

in Harvard Style

Nugraheni R., Yusuf H. and Setyawan D. (2018). The Preservation of Liposomes During Air Drying Using a Matrix Containing Maltodextrin and HPMC.In Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development - Volume 1: MICH-PhD, ISBN 978-989-758-349-0, pages 15-18. DOI: 10.5220/0008238600150018

in Harvard Style

Nugraheni R., Yusuf H. and Setyawan D. (2018). The Preservation of Liposomes During Air Drying Using a Matrix Containing Maltodextrin and HPMC.In Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development - Volume 1: MICH-PhD, ISBN 978-989-758-349-0, pages 15-18. DOI: 10.5220/0008238600150018

in Bibtex Style

@conference{mich-phd18,
author={Raditya Weka Nugraheni and Helmy Yusuf and Dwi Setyawan},
title={The Preservation of Liposomes During Air Drying Using a Matrix Containing Maltodextrin and HPMC},
booktitle={Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development - Volume 1: MICH-PhD,},
year={2018},
pages={15-18},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008238600150018},
isbn={978-989-758-349-0},
}

in Bibtex Style

@conference{mich-phd18,
author={Raditya Weka Nugraheni and Helmy Yusuf and Dwi Setyawan},
title={The Preservation of Liposomes During Air Drying Using a Matrix Containing Maltodextrin and HPMC},
booktitle={Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development - Volume 1: MICH-PhD,},
year={2018},
pages={15-18},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008238600150018},
isbn={978-989-758-349-0},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development - Volume 1: MICH-PhD,
TI - The Preservation of Liposomes During Air Drying Using a Matrix Containing Maltodextrin and HPMC
SN - 978-989-758-349-0
AU - Nugraheni R.
AU - Yusuf H.
AU - Setyawan D.
PY - 2018
SP - 15
EP - 18
DO - 10.5220/0008238600150018

in EndNote Style

TY - CONF

JO - Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development - Volume 1: MICH-PhD,
TI - The Preservation of Liposomes During Air Drying Using a Matrix Containing Maltodextrin and HPMC
SN - 978-989-758-349-0
AU - Nugraheni R.
AU - Yusuf H.
AU - Setyawan D.
PY - 2018
SP - 15
EP - 18
DO - 10.5220/0008238600150018