Anti-Hyperlipidemic Effect of 70% Ethanol Extract from Mesona palustris Blume Leaves on Male Hamsters

Dwitiyanti, Ni Putu Ermi Hikmawanti, Kriana Efendi, Riana Puspa Dewi, Fernita Afriyani

2018

Abstract

In Indonesia, Mesona palustris Blume is known as the black cincau (black grass jelly). This plant has been used for various health condition. This study aims to determine the effectiveness of 70% ethanol extract from black cincau leaves as anti-hyperlipidemic on hyperlipidemic hamsters. The dried leaves were extracted using 70% ethanol by maceration method. Syrian hamsters were divided into 7 groups of 4 hamsters), i.e. normal control group, positive control group (fenofibrate 1.235 mg/Kg body weight), positive control group (atorvastatin 2.4 mg/Kg body weight), negative control group, test groups with 3 dose variations (780, 1560, and 3120 mg/Kg body weight each day). All groups except normal control group were induced with high-fat diet for 28 days. Parameters measured were decreased total blood cholesterol, LDL, triglycerides level, and increased blood HDL level. Treatment was performed for 14 days. The 70% ethanol extract of black cincau with a dose of 3120 mg/Kg body weight was able to decrease blood total cholesterol level by 51.49%, blood LDL level by 49.92%, and blood triglyceride level by 45.70%. Extract with the dose is also able to increase blood HDL level by 29.30%. Fenofibrate was able to decrease blood triglyceride level by 50.62% and increase blood HDL level by 34.82%, whereas atorvastatin was able to decrease blood total cholesterol level by 54.34% and blood LDL level by 51.13%. It could be concluded that the 70% ethanol extract from black cincau leaves is effective as an anti-hyperlipidemic agent in hyperlipidemic hamster equivalent to positive control group.

Paper Citation

in Harvard Style

Dwitiyanti., Hikmawanti N., Efendi K., Dewi R. and Afriyani F. (2018). Anti-Hyperlipidemic Effect of 70% Ethanol Extract from Mesona palustris Blume Leaves on Male Hamsters.In Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development - Volume 1: MICH-PhD, ISBN 978-989-758-349-0, pages 61-65. DOI: 10.5220/0008239400610065

in Harvard Style

Dwitiyanti., Hikmawanti N., Efendi K., Dewi R. and Afriyani F. (2018). Anti-Hyperlipidemic Effect of 70% Ethanol Extract from Mesona palustris Blume Leaves on Male Hamsters.In Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development - Volume 1: MICH-PhD, ISBN 978-989-758-349-0, pages 61-65. DOI: 10.5220/0008239400610065

in Bibtex Style

@conference{mich-phd18,
author={Dwitiyanti and Ni Putu Ermi Hikmawanti and Kriana Efendi and Riana Puspa Dewi and Fernita Afriyani},
title={Anti-Hyperlipidemic Effect of 70% Ethanol Extract from Mesona palustris Blume Leaves on Male Hamsters},
booktitle={Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development - Volume 1: MICH-PhD,},
year={2018},
pages={61-65},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008239400610065},
isbn={978-989-758-349-0},
}

in Bibtex Style

@conference{mich-phd18,
author={Dwitiyanti and Ni Putu Ermi Hikmawanti and Kriana Efendi and Riana Puspa Dewi and Fernita Afriyani},
title={Anti-Hyperlipidemic Effect of 70% Ethanol Extract from Mesona palustris Blume Leaves on Male Hamsters},
booktitle={Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development - Volume 1: MICH-PhD,},
year={2018},
pages={61-65},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008239400610065},
isbn={978-989-758-349-0},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development - Volume 1: MICH-PhD,
TI - Anti-Hyperlipidemic Effect of 70% Ethanol Extract from Mesona palustris Blume Leaves on Male Hamsters
SN - 978-989-758-349-0
AU - Dwitiyanti.
AU - Hikmawanti N.
AU - Efendi K.
AU - Dewi R.
AU - Afriyani F.
PY - 2018
SP - 61
EP - 65
DO - 10.5220/0008239400610065

in EndNote Style

TY - CONF

JO - Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development - Volume 1: MICH-PhD,
TI - Anti-Hyperlipidemic Effect of 70% Ethanol Extract from Mesona palustris Blume Leaves on Male Hamsters
SN - 978-989-758-349-0
AU - Dwitiyanti.
AU - Hikmawanti N.
AU - Efendi K.
AU - Dewi R.
AU - Afriyani F.
PY - 2018
SP - 61
EP - 65
DO - 10.5220/0008239400610065