The Protective Efficacy of Kelakai (Stenochlaena Palustris) on Cadmium-induced Glucose Metabolism Alteration In Vitro

Eko Suhartono, Adenan, Ika Kustiyah Oktaviani, Iskandar Thalib

2018

Abstract

The objectives of this study were to determine the protective effect of kelakai (Stenochlaena palustris) leaves extract on cadmium (Cd)-induced glucose metabolism alteration in vitro. The protective effect of plant extracts extract was determined by assessing the activity of pancreas amylase and liver glucokinase, the concentration of liver glucose, glycogen, and methylglyoxal (MG). In this present study, the liver and pancreas samples were obtained from 32 old male Rattus novergicus. Each model then divided into 4 groups consisting of: pancreas or liver + 0.3 mg/l CdSO4 (T1); pancreas or liver + 0.3 mg/l CdSO4 + 5 mg/l leaves extract (T2); pancreas or liver + 0.3 mg/l CdSO4 + 10 mg/l leaves extract (T3); and pancreas or liver + 0.3 mg/l CdSO4 + 15 mg/l leaves extract (T4). Results of this present study shows that the administration of S. palustris leaves extract could significantly decreased the pancreas amylase activity, the level of liver glucose and MG, and significantly increase the liver glucokinase activity, and the level of liver glycogen (P < 0.05). In conclusions, the results of this present study indicated that the administration of S. palustris leaves extract could improve the glucose metabolism alteration by Cd.

Paper Citation

in Harvard Style

Suhartono E., Oktaviani I., Adenan. and Thalib I. (2018). The Protective Efficacy of Kelakai (Stenochlaena Palustris) on Cadmium-induced Glucose Metabolism Alteration In Vitro.In Proceedings of the 2nd Syiah Kuala International Conference on Medicine and Health Sciences - Volume 1: SKIC-MHS, ISBN 978-989-758-438-1, pages 156-162. DOI: 10.5220/0008788101560162

in Bibtex Style

@conference{skic-mhs18,
author={Eko Suhartono and Ika Kustiyah Oktaviani and Adenan and Iskandar Thalib},
title={The Protective Efficacy of Kelakai (Stenochlaena Palustris) on Cadmium-induced Glucose Metabolism Alteration In Vitro},
booktitle={Proceedings of the 2nd Syiah Kuala International Conference on Medicine and Health Sciences - Volume 1: SKIC-MHS,},
year={2018},
pages={156-162},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008788101560162},
isbn={978-989-758-438-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd Syiah Kuala International Conference on Medicine and Health Sciences - Volume 1: SKIC-MHS,
TI - The Protective Efficacy of Kelakai (Stenochlaena Palustris) on Cadmium-induced Glucose Metabolism Alteration In Vitro
SN - 978-989-758-438-1
AU - Suhartono E.
AU - Oktaviani I.
AU - Adenan.
AU - Thalib I.
PY - 2018
SP - 156
EP - 162
DO - 10.5220/0008788101560162