Butyrate Acid as a Potential Marker for Diversity of Gut Microbiota in Colorectal Cancer Patients

Fauzi Yusuf, Azzaki Abubakar, Desi Maghfirah, Siti Adewiyah

2018

Abstract

The gut microbiota acts as a real organ and many changes in its composition have been reported in colorectal cancer (CRC). Short-chain fatty acids (SCFA) mainly produced as microbial metabolites, acetate, propionate, and butyrate acids. Butyrate is produced by specific bacteria, mainly in the colon, and is taken up by the host. In our study, we found that CRC patients had lower level of acetate, propionate and butyrate acids than non-CRC. The mean concentration of acetate 8,55 µg/mL, propionate 5,61 µg/mL and butyrate acids 3,79 µg/mL respectively. In three of SCFA, the level of butyrate acids had the best diagnostic properties with area under receiver operating characteristic (ROC) curve of 0.84 higher than acetate (0.71) and propionate (0.75) (p< 0.05).

Paper Citation

in Harvard Style

Yusuf F., Abubakar A., Maghfirah D. and Adewiyah S. (2018). Butyrate Acid as a Potential Marker for Diversity of Gut Microbiota in Colorectal Cancer Patients.In Proceedings of the 2nd Syiah Kuala International Conference on Medicine and Health Sciences - Volume 1: SKIC-MHS, ISBN 978-989-758-438-1, pages 27-30. DOI: 10.5220/0008790200270030

in Bibtex Style

@conference{skic-mhs18,
author={Fauzi Yusuf and Azzaki Abubakar and Desi Maghfirah and Siti Adewiyah},
title={Butyrate Acid as a Potential Marker for Diversity of Gut Microbiota in Colorectal Cancer Patients},
booktitle={Proceedings of the 2nd Syiah Kuala International Conference on Medicine and Health Sciences - Volume 1: SKIC-MHS,},
year={2018},
pages={27-30},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008790200270030},
isbn={978-989-758-438-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd Syiah Kuala International Conference on Medicine and Health Sciences - Volume 1: SKIC-MHS,
TI - Butyrate Acid as a Potential Marker for Diversity of Gut Microbiota in Colorectal Cancer Patients
SN - 978-989-758-438-1
AU - Yusuf F.
AU - Abubakar A.
AU - Maghfirah D.
AU - Adewiyah S.
PY - 2018
SP - 27
EP - 30
DO - 10.5220/0008790200270030