In Vitro Effect of 96% Ethanol Extract of Bitter Herbs (Andrographis paniculata Nees) on Heme Detoxification Process of Plasmodium falciparum Parasites

Safarianti, Aty Widyawaruyanti, Hilkatul Ilmi, Achmad Fuad, Maryatun, Indah Tantular

2018

Abstract

Malaria still becomes a global health problem especially in tropical countries and developing countries. The number of malaria infections in Indonesia is still high and it becomes endemic disease in some areas. The high rate incidence of malaria can be caused by the emergence of malaria parasite strains that are resistant to anti malarial drugs. Various efforts have been made to reduce the incidence of malaria, one of which was to develop a new medicinal compounds from natural ingredients such as 96% ethanol extract of bitter herbs (Andrographis paniculata Nees). This herb has been proven to have antimalarial activity both in-vitro and in-vivo from previous studies. This study aims to determine the effect of 96% ethanol extract of bitter herbs on heme detoxification process of Plasmodum falciparum through the inhibition of β-hematin formation (synthetic heme). This research is a laboratory experimental research that was conducted in Malaria Laboratory of Institute of Tropical Disease (ITD) University of Airlangga Surabaya. The results showed that 96% ethanol extract of bitter herbs inhibits the formation of β-hematin equal to 61,07 ± 4,69%. It can be concluded that 96% ethanol extract of bitter herbs (Andrographis paniculate Nees) are able to inhibit heme detoxification process of Plasmodium falciparum parasites.

Paper Citation

in Harvard Style

Safarianti., Widyawaruyanti A., Ilmi H., Fuad A., Maryatun. and Tantular I. (2018). In Vitro Effect of 96% Ethanol Extract of Bitter Herbs (Andrographis paniculata Nees) on Heme Detoxification Process of Plasmodium falciparum Parasites.In Proceedings of the 2nd Syiah Kuala International Conference on Medicine and Health Sciences - Volume 1: SKIC-MHS, ISBN 978-989-758-438-1, pages 72-75. DOI: 10.5220/0008791100720075

in Bibtex Style

@conference{skic-mhs18,
author={Safarianti and Aty Widyawaruyanti and Hilkatul Ilmi and Achmad Fuad and Maryatun and Indah Tantular},
title={In Vitro Effect of 96% Ethanol Extract of Bitter Herbs (Andrographis paniculata Nees) on Heme Detoxification Process of Plasmodium falciparum Parasites},
booktitle={Proceedings of the 2nd Syiah Kuala International Conference on Medicine and Health Sciences - Volume 1: SKIC-MHS,},
year={2018},
pages={72-75},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008791100720075},
isbn={978-989-758-438-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd Syiah Kuala International Conference on Medicine and Health Sciences - Volume 1: SKIC-MHS,
TI - In Vitro Effect of 96% Ethanol Extract of Bitter Herbs (Andrographis paniculata Nees) on Heme Detoxification Process of Plasmodium falciparum Parasites
SN - 978-989-758-438-1
AU - Safarianti.
AU - Widyawaruyanti A.
AU - Ilmi H.
AU - Fuad A.
AU - Maryatun.
AU - Tantular I.
PY - 2018
SP - 72
EP - 75
DO - 10.5220/0008791100720075