Paracetamol for Patent Ductus Arteriosus in Preterm or Term Infants

Herlina Dimiati, Dora Darussalam, Isra Firmansyah

2018

Abstract

The aim of this study was to present our experience with intravenous paracetamol for closing of PDA in neonates contraindicated to ibuprofen or ibuprophen had failed and no candidates for surgical ligation. We conducted study in the Neonatal Intensive Care Unit (NICU) Dr. Zainoel Abidin Hospital and Harapan Bunda Hospital in Banda Aceh, from January to December 2017 with hemodynamic significant PDA (hsPDA). All the subject received 15 mg/kg/6 h intravenous paracetamol for 3 days for ductal closure, and evaluation ductal with echocardiography on the 5th day after the regiment. Seventy-two (72) neonates were diagnosed of hsPDA, mean gestational age (GA) of 34.26 weeks and mean birth weight of 1945.69 grams, female babies were 39 (54.2%) and male babies were 33 (45.8%). Preterm babies were 45 (62.5%) and full-term babies were 27 (37.5%). Twenty- six (36.1%%) babies had closed PDAs on the 5th days evaluation, 11 babies (15.3%) had twice regiment , closed PDA at the 10th days evaluation, and 35 babies (48.6%) had more closed PDA after three or four regiment. Successful closure on paracetamol was achieved in 51 babies (70.8%). And 21 (29.2%) had failed PDA closure. Paracetamol is an effective option in closure PDA and should be a first-line therapeutic option when there are contraindications for ibuprofen.

Paper Citation

in Harvard Style

Dimiati H., Darussalam D. and Firmansyah I. (2018). Paracetamol for Patent Ductus Arteriosus in Preterm or Term Infants.In Proceedings of the 2nd Syiah Kuala International Conference on Medicine and Health Sciences - Volume 1: SKIC-MHS, ISBN 978-989-758-438-1, pages 223-227. DOI: 10.5220/0008792202230227

in Bibtex Style

@conference{skic-mhs18,
author={Herlina Dimiati and Dora Darussalam and Isra Firmansyah},
title={Paracetamol for Patent Ductus Arteriosus in Preterm or Term Infants},
booktitle={Proceedings of the 2nd Syiah Kuala International Conference on Medicine and Health Sciences - Volume 1: SKIC-MHS,},
year={2018},
pages={223-227},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008792202230227},
isbn={978-989-758-438-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd Syiah Kuala International Conference on Medicine and Health Sciences - Volume 1: SKIC-MHS,
TI - Paracetamol for Patent Ductus Arteriosus in Preterm or Term Infants
SN - 978-989-758-438-1
AU - Dimiati H.
AU - Darussalam D.
AU - Firmansyah I.
PY - 2018
SP - 223
EP - 227
DO - 10.5220/0008792202230227