Characterization of Hemagglutinin Protein Structure of H5N1 Virus Circulating in Indonesia based on Proteomic Analysis

Moch Irfan Hadi, Hanik Faizah, M Yusuf Alamudi, Misbakhul Munir, Risa Purnamasari, Nova Lusiana

2018

Abstract

Bird flu virus or H5N1 is one of the infectious agents that still become a global problem. Based on data from the World Health Organization (WHO) until June 15, 2017, more than 800 people were infected with the H5N1 virus, and nearly 500 people died. Indonesia is the 2nd country in the world with the highest number of infected bird flu virus that is 199 people infected and 167 people died, with more than 70% case fatality rate. Influenza A especially H5N1 has eight genes, one of them is Hemagglutinin. Hemagglutinin (HA) protein present on the surface of the virus. The presence of a "cleavage site" in HA protein will improve the pathogenic nature of the AI virus. HA protein also plays a role in the process of viral infection into cells by interacting directly with receptors on the surface of the host cell. Besides, HA protein also functions in the movement of the virus from one cell to another cell. Through the accumulation of mutations in HA, the AI virus can increase its infectious potency. The purpose of this study was to characterize the Hemagglutinin of bird flu virus in Indonesia by using bioinformatics method. The study discovered the differences in the characterization of bird flu virus circulating in Indonesia based on the proteomic analysis.

Paper Citation

in Harvard Style

Hadi M., Faizah H., Alamudi M., Munir M., Purnamasari R. and Lusiana N. (2018). Characterization of Hemagglutinin Protein Structure of H5N1 Virus Circulating in Indonesia based on Proteomic Analysis. In Proceedings of the Built Environment, Science and Technology International Conference - Volume 1: BEST ICON, ISBN 978-989-758-414-5, pages 95-98. DOI: 10.5220/0008903700002481

in Bibtex Style

@conference{best icon18,
author={Moch Irfan Hadi and Hanik Faizah and M Yusuf Alamudi and Misbakhul Munir and Risa Purnamasari and Nova Lusiana},
title={Characterization of Hemagglutinin Protein Structure of H5N1 Virus Circulating in Indonesia based on Proteomic Analysis},
booktitle={Proceedings of the Built Environment, Science and Technology International Conference - Volume 1: BEST ICON,},
year={2018},
pages={95-98},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008903700002481},
isbn={978-989-758-414-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the Built Environment, Science and Technology International Conference - Volume 1: BEST ICON,
TI - Characterization of Hemagglutinin Protein Structure of H5N1 Virus Circulating in Indonesia based on Proteomic Analysis
SN - 978-989-758-414-5
AU - Hadi M.
AU - Faizah H.
AU - Alamudi M.
AU - Munir M.
AU - Purnamasari R.
AU - Lusiana N.
PY - 2018
SP - 95
EP - 98
DO - 10.5220/0008903700002481