Anti-hyperlipidemic Activity of Methanolic Extract of Impatiens Balsamina L. in Hypercholestrolemic Induced Sprague Dawley Rats

Santosh Fattepur, Kiran Chanabasappa Nilugal, Thurga Devi Balan, May Florence Dela Cruz Bacayo, Wong Charng Choon, Mohamed Rasny Mohamed Razik, Fadli Asmani, Eddy Yusuf

2018

Abstract

Background &amp; Aim: The occurrence of hyperlipidemia, is currently increasing at a remarkable rate throughout the world. Hyperlipidemia graded as one of the greatest risk factors that contributes to the prevalence and severity of life threatening coronary heart diseases. Medicinal plants and their products are safer than their synthetic counterparts, including those involved in the anti-hyperlipidemic drugs statins. Impatiens Balsamina (IB) is used medicinally for various ailments. No study was carried out on the anti-cholesterol activity of IB. Objective: To study anti-hyperlipidemic activity of methanolic extracts of IB (MEIB) in hypercholesterolemia induced Sprague Dawley rats. Materials & Method: MEIB leaves were prepared using maceration method. Toxicity study was carried out using OECD guidelines. Hypercholesterolemia in rats was induced by using 6% of lard oil, 2% of cheese and egg yolk. Two different doses 200 and 400mg/kg of MEIB were used to study for anti hyperlipidemic activity. Histopathological study was carried out in rats. Results: No mortality was observed even up to 2g/kg. Only 400mg/kg of MEIB statistically decreased in total cholesterol (P < 0.05), LDL-cholesterol (P < 0.05) and an increase in HDL-cholesterol (P < 0.05) as compared to the positive control. Histopathology study revealed that 400mg/kg MEIB leaves administered group have mild steatosis and no inflammation as compared to control group. Conclusion: MEIB could be a potential herbal medicine as adjuvant with existing therapy for the treatment of hyperlipidemia.

Paper Citation

in Harvard Style

Fattepur S., Nilugal K., Balan T., Bacayo M., Choon W., Razik M., Asmani F. and Yusuf E. (2018). Anti-hyperlipidemic Activity of Methanolic Extract of Impatiens Balsamina L. in Hypercholestrolemic Induced Sprague Dawley Rats. In Proceedings of BROMO Conference - Volume 1: BROMO, ISBN 978-989-758-347-6, pages 1-1. DOI: 10.5220/0009842200002406

in Bibtex Style

@conference{bromo18,
author={Santosh Fattepur and Kiran Chanabasappa Nilugal and Thurga Devi Balan and May Florence Dela Cruz Bacayo and Wong Charng Choon and Mohamed Rasny Mohamed Razik and Fadli Asmani and Eddy Yusuf},
title={Anti-hyperlipidemic Activity of Methanolic Extract of Impatiens Balsamina L. in Hypercholestrolemic Induced Sprague Dawley Rats},
booktitle={Proceedings of BROMO Conference - Volume 1: BROMO,},
year={2018},
pages={1-1},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009842200002406},
isbn={978-989-758-347-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of BROMO Conference - Volume 1: BROMO,
TI - Anti-hyperlipidemic Activity of Methanolic Extract of Impatiens Balsamina L. in Hypercholestrolemic Induced Sprague Dawley Rats
SN - 978-989-758-347-6
AU - Fattepur S.
AU - Nilugal K.
AU - Balan T.
AU - Bacayo M.
AU - Choon W.
AU - Razik M.
AU - Asmani F.
AU - Yusuf E.
PY - 2018
SP - 1
EP - 1
DO - 10.5220/0009842200002406