Evaluation of Anti-ulcer Effect of Papaya Juice in Combination with Cumin Seed in Ethanol Induced Peptic ulcers in Experimental Rats

Kiran Chanabasappa Nilugal, Santosh Fattepur, Visallani Veerapandian, Fadli Asmani, May Florence Dela Cruz Bacayo, Ibrahim Abdulah, Eddy Yusuf

2018

Abstract

BACKGROUND: A disease which impairs the quality of life and associated with increased morbidity and mortality and a worldwide problem is known as peptic ulcer. Ulceration is resulting with the elevated acid secretion, and diminished mucosal resistance due to Helicobacter pylori infection, NSAID's, alcohol intake and tobacco smoking. OBJECTIVES: This study was carried out to find out the anti-ulcer activity of papaya juice mixed with cumin seed extract in ethanol induced peptic ulcer in rats. METHOD: Healthy adult female albino rats were used for this study. The rats were divided into five groups with six rats each. Omeprazole 20mg/kg were used as a standard drug. Group 1: Control group, Group 2: Positive group, Group 3: Standard group which received Omeprazole, Group 4: Extract test group which received papaya juice (20ml/kg) mixed with cumin seed with strength of (2.5ml/kg), Group 5: Extract test group which receives papaya juice (20ml/kg) mixed with cumin seed with the strength of (5ml/kg). Ethanol will be given in dose of 1ml per rat orally to Group 2, 3, 4 and 5 animal groups on the 8 th day of experiment. The rats were sacrificed and stomachs were opened. Ulcer index and histological changes were studied. RESULT: The results of the study exhibit that papaya juice in combination with cumin seed extract has significant anti-ulcer activity with p value <0.05 through statistical analysis and there is decrease in ulcer score comparable to omeprazole. CONCLUSION: the extract group has has better ulcer protective compared to control indicating the plants possess significant anti-ulcer property in a dose dependent manner.

Paper Citation

in Harvard Style

Nilugal K., Fattepur S., Veerapandian V., Asmani F., Bacayo M., Abdulah I. and Yusuf E. (2018). Evaluation of Anti-ulcer Effect of Papaya Juice in Combination with Cumin Seed in Ethanol Induced Peptic ulcers in Experimental Rats. In Proceedings of BROMO Conference - Volume 1: BROMO, ISBN 978-989-758-347-6, pages 1-1. DOI: 10.5220/0009842600002406

in Bibtex Style

@conference{bromo18,
author={Kiran Chanabasappa Nilugal and Santosh Fattepur and Visallani Veerapandian and Fadli Asmani and May Florence Dela Cruz Bacayo and Ibrahim Abdulah and Eddy Yusuf},
title={Evaluation of Anti-ulcer Effect of Papaya Juice in Combination with Cumin Seed in Ethanol Induced Peptic ulcers in Experimental Rats},
booktitle={Proceedings of BROMO Conference - Volume 1: BROMO,},
year={2018},
pages={1-1},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009842600002406},
isbn={978-989-758-347-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of BROMO Conference - Volume 1: BROMO,
TI - Evaluation of Anti-ulcer Effect of Papaya Juice in Combination with Cumin Seed in Ethanol Induced Peptic ulcers in Experimental Rats
SN - 978-989-758-347-6
AU - Nilugal K.
AU - Fattepur S.
AU - Veerapandian V.
AU - Asmani F.
AU - Bacayo M.
AU - Abdulah I.
AU - Yusuf E.
PY - 2018
SP - 1
EP - 1
DO - 10.5220/0009842600002406