The Effect of Centella asiatica on Brain Malondialdehyde Levels of Aged Rats

Nathaniel Aditya, Indah Fitriani, Desak Gede Budi Krisnamurti, Desak Gede Budi Krisnamurti, Siti Farida, Siti Farida, Erni Hernawati Purwaningsih, Erni Hernawati Purwaningsih, Rani Wardani Hakim, Rani Wardani Hakim

2018

Abstract

Background: In 2050, the number of elderly with 65 years of age or more is estimated to reach 1.5 billion. To better anticipate this problem, a shift of paradigm, from chronological to biological aging, is needed. Aging is a multifactorial process closely related to oxidative stress, a phenomenon in which the rate can be indicated through its secondary metabolite level, malondialdehyde (MDA). Objective: This study examines the effect of a well-known traditional medicinal plant used for its anti-inflammatory properties, Centella asiatica (CA), to brain MDA levels in aged Sprague-Dawley rats. Methods: The aged male rats were divided into three groups: negative control, positive control (vitamin E 6 IU), treatment (CA leaves ethanolic extract 300 mg/kg), with one additional group of untreated young rats. Throughout 28 days, each rat was given the corresponding treatment. The brains then were collected to be studied using the Lipid Peroxidation (MDA) Assay Kit. One-way ANOVA is the choice of the statistical analysis method. Results: We found that the level of MDA in the brain tissues of the treatment group rats had a lower value compared to that of the control group, although statistically insignificant (P = 0.5683). Unquestionably, the MDA concentration in the vitamin E-treated rats is the lowest of all. Conclusion: These results implied that CA may exhibit an antioxidative effect on aged rats which could hinder an aging process, if not prevent it.

Paper Citation

in Harvard Style

Aditya N., Fitriani I., Krisnamurti D., Farida S., Purwaningsih E. and Hakim R. (2018). The Effect of Centella asiatica on Brain Malondialdehyde Levels of Aged Rats. In Proceedings of BROMO Conference - Volume 1: BROMO, ISBN 978-989-758-347-6, pages 1-1. DOI: 10.5220/0009844700002406

in Bibtex Style

@conference{bromo18,
author={Nathaniel Aditya and Indah Fitriani and Desak Gede Budi Krisnamurti and Siti Farida and Erni Hernawati Purwaningsih and Rani Wardani Hakim},
title={The Effect of Centella asiatica on Brain Malondialdehyde Levels of Aged Rats},
booktitle={Proceedings of BROMO Conference - Volume 1: BROMO,},
year={2018},
pages={1-1},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009844700002406},
isbn={978-989-758-347-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of BROMO Conference - Volume 1: BROMO,
TI - The Effect of Centella asiatica on Brain Malondialdehyde Levels of Aged Rats
SN - 978-989-758-347-6
AU - Aditya N.
AU - Fitriani I.
AU - Krisnamurti D.
AU - Farida S.
AU - Purwaningsih E.
AU - Hakim R.
PY - 2018
SP - 1
EP - 1
DO - 10.5220/0009844700002406