Synthesis, Antioxidant and Toxicity Activity of Compounds (E)-1-(3-bromophenyl)-3-p tolylprop-2-en-1-on

Eti Meirina Brahmana, Jamaran Kaban, Ginda Haro, Juliati Br Tarigan, Basuki Wirjosentono, Tamrin, Mimpin Ginting

2019

Abstract

Halogen substituted analog compound chalcone (E)-1-(3-bromophenyl)-3-p-tolylprop-2-en-1-on was synthesized from 4-metylbenzaldehyde as aldehydes with 3- bromoacetophenone, as ketones by using aldol condensation reaction. The compound resulted rendement with value of 62,38% and characterized by using UV, IR, MS, and 1HNMR. Test of antioxidant activity using DPPH method showed that those compounds have low potency as antioxidant agent LC50 with value 571, 7903 ppm. Toxicity tests using Brine Shrimp Lethality Test (BSLT) showed that those compounds have a potency as anticancer agent with LC50 value 7,94 μg/mL.

Paper Citation

in Harvard Style

Brahmana E., Kaban J., Haro G., Br Tarigan J., Wirjosentono B., Tamrin. and Ginting M. (2019). Synthesis, Antioxidant and Toxicity Activity of Compounds (E)-1-(3-bromophenyl)-3-p tolylprop-2-en-1-on.In Proceedings of the 1st International Conference on Chemical Science and Technology Innovation - Volume 1: ICOCSTI, ISBN 978-989-758-415-2, pages 5-9. DOI: 10.5220/0008836400050009

in Bibtex Style

@conference{icocsti19,
author={Eti Meirina Brahmana and Jamaran Kaban and Ginda Haro and Juliati Br Tarigan and Basuki Wirjosentono and Tamrin and Mimpin Ginting},
title={Synthesis, Antioxidant and Toxicity Activity of Compounds (E)-1-(3-bromophenyl)-3-p tolylprop-2-en-1-on},
booktitle={Proceedings of the 1st International Conference on Chemical Science and Technology Innovation - Volume 1: ICOCSTI,},
year={2019},
pages={5-9},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008836400050009},
isbn={978-989-758-415-2},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Chemical Science and Technology Innovation - Volume 1: ICOCSTI,
TI - Synthesis, Antioxidant and Toxicity Activity of Compounds (E)-1-(3-bromophenyl)-3-p tolylprop-2-en-1-on
SN - 978-989-758-415-2
AU - Brahmana E.
AU - Kaban J.
AU - Haro G.
AU - Br Tarigan J.
AU - Wirjosentono B.
AU - Tamrin.
AU - Ginting M.
PY - 2019
SP - 5
EP - 9
DO - 10.5220/0008836400050009