Cytotoxicity of Heterophyllene A, the Derivative of Arylbenzofuran from Stem Bark of Artocarpus calophylla

Rumzil Laili, Nanik Siti Aminah, Tin Myo Thant, Ainun Sa'adah, Yoshiaki Takaya, Alfinda Novi Kristanti

2019

Abstract

Exploration of secondary metabolites was the focus of this research, especially of Artocarpus calophylla species to look for a potential cytotoxic agent. An arylbenzofuran derivative compound, namely heterophyllene A was isolated from the stem bark of Artocarpus calophylla. Structure determination of this compound has been elucidated using UV-Vis spectroscopy, 1D, and 2D NMR analysis. This compound has a lower IC50 than ethyl acetate extract. The IC50 of this compound (57,54 µg/mL) to HeLa and (25,80 µg/mL) to T47D cells, ethyl acetate extract (>100 µg/mL) to HeLa and (84,16 µg/mL) to T47D cells.

Paper Citation

in Harvard Style

Laili R., Siti Aminah N., Myo Thant T., Takaya Y., Sa'adah A. and Novi Kristanti A. (2019). Cytotoxicity of Heterophyllene A, the Derivative of Arylbenzofuran from Stem Bark of Artocarpus calophylla.In Proceedings of the 1st International Conference on Chemical Science and Technology Innovation - Volume 1: ICOCSTI, ISBN 978-989-758-415-2, pages 156-159. DOI: 10.5220/0008863201560159

in Bibtex Style

@conference{icocsti19,
author={Rumzil Laili and Nanik Siti Aminah and Tin Myo Thant and Yoshiaki Takaya and Ainun Sa'adah and Alfinda Novi Kristanti},
title={Cytotoxicity of Heterophyllene A, the Derivative of Arylbenzofuran from Stem Bark of Artocarpus calophylla},
booktitle={Proceedings of the 1st International Conference on Chemical Science and Technology Innovation - Volume 1: ICOCSTI,},
year={2019},
pages={156-159},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008863201560159},
isbn={978-989-758-415-2},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Chemical Science and Technology Innovation - Volume 1: ICOCSTI,
TI - Cytotoxicity of Heterophyllene A, the Derivative of Arylbenzofuran from Stem Bark of Artocarpus calophylla
SN - 978-989-758-415-2
AU - Laili R.
AU - Siti Aminah N.
AU - Myo Thant T.
AU - Takaya Y.
AU - Sa'adah A.
AU - Novi Kristanti A.
PY - 2019
SP - 156
EP - 159
DO - 10.5220/0008863201560159