Synthesis of Quatenary Ammonium Compounds from Eugenol through Mannich and Methylation Reactions and Its Antibacterial Activity

Sabarmin Perangin-angin, Sri Wahyuni Barus

2019

Abstract

6-[(N-iodo-N-methyl-N-methyl-N-methylamino)methyl]-4-alyl-2-methoxyphenol was synthesized through Mannich and methylation reaction. Mannich reaction was carried out by reacting eugenol, formaldehyde 37%, and dimethylamine 40% with ethanol at temperature of 78°C for 90 minutes and 4-allyl-6-(dimethylamino)methyl-2-methoxyphenol was obtained with yield of 83,03%. Quartenary ammonium salt, 6-[(N-iodo-N-methyl-N-methyl-N-methylamino)methyl]-4-allyl-2-methoxyphenol, was obtained through methylation reaction of 4-allyl-6-(dimethylamino)methyl-2-methoxyphenol with methyl iodide in ethanol. In the FTIR spectrum, the specific peak of ammonium salt was exhibited at 948.98 and 455.20 cm-1. The antibacterial activity of 6-[(N-iodo-N-metil-N-methyl-N-methylamino)methyl]-4-allyl-2-methoxyphenol was performed against E. coli and S. aureus, this quaternary ammonium salt exhibited a strong activity.

Paper Citation

in Harvard Style

Perangin-angin S. and Wahyuni Barus S. (2019). Synthesis of Quatenary Ammonium Compounds from Eugenol through Mannich and Methylation Reactions and Its Antibacterial Activity.In Proceedings of the 1st International Conference on Chemical Science and Technology Innovation - Volume 1: ICOCSTI, ISBN 978-989-758-415-2, pages 223-228. DOI: 10.5220/0008879202230228

in Bibtex Style

@conference{icocsti19,
author={Sabarmin Perangin-angin and Sri Wahyuni Barus},
title={Synthesis of Quatenary Ammonium Compounds from Eugenol through Mannich and Methylation Reactions and Its Antibacterial Activity},
booktitle={Proceedings of the 1st International Conference on Chemical Science and Technology Innovation - Volume 1: ICOCSTI,},
year={2019},
pages={223-228},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008879202230228},
isbn={978-989-758-415-2},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Chemical Science and Technology Innovation - Volume 1: ICOCSTI,
TI - Synthesis of Quatenary Ammonium Compounds from Eugenol through Mannich and Methylation Reactions and Its Antibacterial Activity
SN - 978-989-758-415-2
AU - Perangin-angin S.
AU - Wahyuni Barus S.
PY - 2019
SP - 223
EP - 228
DO - 10.5220/0008879202230228