Synthesis 2-(3-Phenylallylidenamino) Pentanedioic Acid by Condensation of Cinnamaldehyde with Glutamic Acid and the Activity Test as Antibact

Mimpin Ginting, Deni Aprilina Lumban Gaul, Indra Masmur, Andy Candra

2019

Abstract

2-(3- Phenylallyldenamino) Pentanedioic Acid as Schiff base has been synthesize by condensation between cinnamaldehyde and glutamic acid as the source of primary amine. Condensation between cinnamaldehyde and glutamic acid is in reflux condition by using ethanol as a solvent for 5 hours. Rendemen of reaction is 49.39%. The formed Schiff base is proven by FT-IR spectrum with the appearance of a vibration peak at wave number in 1627 cm-1 as the sign of C=N functional group. UV-Vis spectrum showed the change of cinnamaldehyde maximum wave number in 238 nm become Schiff base in 321 nm. The result of research also show that the Schiff base has strong antibacterial activity for S. aureus by obstacle zone 13.3 mm and weak antibacterial activity for E.coli by obstacle zone 6.6 mm.

Paper Citation

in Harvard Style

Ginting M., Aprilina Lumban Gaul D., Masmur I. and Candra A. (2019). Synthesis 2-(3-Phenylallylidenamino) Pentanedioic Acid by Condensation of Cinnamaldehyde with Glutamic Acid and the Activity Test as Antibact.In Proceedings of the 1st International Conference on Chemical Science and Technology Innovation - Volume 1: ICOCSTI, ISBN 978-989-758-415-2, pages 229-233. DOI: 10.5220/0008919702290233

in Bibtex Style

@conference{icocsti19,
author={Mimpin Ginting and Deni Aprilina Lumban Gaul and Indra Masmur and Andy Candra},
title={Synthesis 2-(3-Phenylallylidenamino) Pentanedioic Acid by Condensation of Cinnamaldehyde with Glutamic Acid and the Activity Test as Antibact},
booktitle={Proceedings of the 1st International Conference on Chemical Science and Technology Innovation - Volume 1: ICOCSTI,},
year={2019},
pages={229-233},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008919702290233},
isbn={978-989-758-415-2},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Chemical Science and Technology Innovation - Volume 1: ICOCSTI,
TI - Synthesis 2-(3-Phenylallylidenamino) Pentanedioic Acid by Condensation of Cinnamaldehyde with Glutamic Acid and the Activity Test as Antibact
SN - 978-989-758-415-2
AU - Ginting M.
AU - Aprilina Lumban Gaul D.
AU - Masmur I.
AU - Candra A.
PY - 2019
SP - 229
EP - 233
DO - 10.5220/0008919702290233