The Effect of Epinephrine Administration on the Level of Gonadotropin Hormones of Japan Strain Female Mice (Mus Musculus)

Aulia Asman, Debby Sinthania, Linda Marni

2019

Abstract

Physical, chemical, and psychological stressors can affect the pulsatile frequency and amplitude of GnRH; this is important for FSH and LH secretion. Excessive increase in pulsation can reduce and stop FSH and LH secretion. This study aimed to prove the effect of epinephrine to FSH and LH levels. This study was an experimental laboratory with a post-test only control group design. This study used 24 female mice (Mus musculus) consisting of 6 groups, namely 1 control group and 5 treatment groups based on differences in the administration of epinephrine of 0.001 mg/ml, 0.002 mg/ml, 0.003 mg/ml, 0.004 mg/ml, and 0.005 mg/ml applied every day for 20 days starting at the beginning of the pro-estrus cycle. The results were analyzed using the One-Way ANOVA continued Multiple Comparisons Bonferroni test. The results showed that the dose difference in the administration of epinephrine gave a significant difference (p <0.05) on FSH and LH levels starting at 0.001 mg/ml and 0.002 mg/ml, 0.003 mg/ml, 0.004 mg/ml, 0.005 mg/ml with control. It can be concluded that chemical stressors (epinephrine) can reduce FSH and LH levels. It is recommended that further research adds measurements on the levels of estrogen and progesterone and the levels of catecholamine.

Paper Citation

in Harvard Style

Asman A., Sinthania D. and Marni L. (2019). The Effect of Epinephrine Administration on the Level of Gonadotropin Hormones of Japan Strain Female Mice (Mus Musculus).In Proceedings of the 2nd Health Science International Conference - Volume 1: HSIC, ISBN 978-989-758-462-6, pages 119-123. DOI: 10.5220/0009124301190123

in Bibtex Style

@conference{hsic19,
author={Aulia Asman and Debby Sinthania and Linda Marni},
title={The Effect of Epinephrine Administration on the Level of Gonadotropin Hormones of Japan Strain Female Mice (Mus Musculus)},
booktitle={Proceedings of the 2nd Health Science International Conference - Volume 1: HSIC,},
year={2019},
pages={119-123},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009124301190123},
isbn={978-989-758-462-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd Health Science International Conference - Volume 1: HSIC,
TI - The Effect of Epinephrine Administration on the Level of Gonadotropin Hormones of Japan Strain Female Mice (Mus Musculus)
SN - 978-989-758-462-6
AU - Asman A.
AU - Sinthania D.
AU - Marni L.
PY - 2019
SP - 119
EP - 123
DO - 10.5220/0009124301190123