HPMC Inhibit Mannitol Re-crystallization in Air-dried Liposome Formulations

Raditya Weka Nugraheni, Helmy Yusuf, Dwi Setyawan

2019

Abstract

Liposome defined as a spherical vesicle, which is formed when phospholipids are being hydrated with an aqueous environment. This study investigated the role of HPMC to inhibit mannitol crystallization in the air-dried liposome formulation. HPMC has been used in solid dispersion to prevent crystallization drugs. The mannitol and HPMC were included in the developed formulations with four different ratios and air-dried at 40ºC for 120 h. Liposome was composed of SPC:DDA: Chol (9:3:1 in molar ratio). XRD data showed crystalline-forming properties as a function of mannitol and HPMC ratio. The formula with the highest mannitol: HPMC ratio (4:1) showed the most apparent crystallinity, while the lowest proportion (2:3) indicated amorphous solid. DTA analysis found that the following formula showed a broad endothermic peak at 150-170ºC, indicating amorphous solid. SEM data supported these results where no crystalline structure was observed in the latter formulation. The rest formula showed partially amorphous and partially crystalline. It can be concluded that the incorporation of HPMC as a dispersion matrix potentially inhibits crystal formation in the developed formulation

Paper Citation

in Harvard Style

Nugraheni R., Yusuf H. and Setyawan D. (2019). HPMC Inhibit Mannitol Re-crystallization in Air-dried Liposome Formulations.In Proceedings of the 2nd Health Science International Conference - Volume 1: HSIC, ISBN 978-989-758-462-6, pages 228-232. DOI: 10.5220/0009130502280232

in Bibtex Style

@conference{hsic19,
author={Raditya Weka Nugraheni and Helmy Yusuf and Dwi Setyawan},
title={HPMC Inhibit Mannitol Re-crystallization in Air-dried Liposome Formulations},
booktitle={Proceedings of the 2nd Health Science International Conference - Volume 1: HSIC,},
year={2019},
pages={228-232},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009130502280232},
isbn={978-989-758-462-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd Health Science International Conference - Volume 1: HSIC,
TI - HPMC Inhibit Mannitol Re-crystallization in Air-dried Liposome Formulations
SN - 978-989-758-462-6
AU - Nugraheni R.
AU - Yusuf H.
AU - Setyawan D.
PY - 2019
SP - 228
EP - 232
DO - 10.5220/0009130502280232