Turmeric Extract Administration Increases the Expression of Brain Derived Neurotropic Factor Following Repetitive Traumatic Brain Injuries

Andre Marolop Pangihutan Siahaan, Iskandar Japardi, Wismaji Sadewo

2019

Abstract

Objective: To demonstrate the role of turmeric extract administration in increasing Brain-Derived Neurotrophic Factor (BDNF). Method: A model of repetitive traumatic brain injury was used on Sprague Dawley mouse, using a 40-gr weight dropped onto the vertex from 1-m height with total frequency of twelve times, divided into four days; three traumas every day. A 500 mg/kg turmeric extract was administered per oral daily. BDNF expression was assessed using immunohistochemistry examination. As a comparison, there were also negative sham control group and trauma only group. Result: There was no significant difference in BDNF expression between the negative sham control group and trauma only group. Instead, there was a significant increase in BDNF expression in the group with turmeric extract administration. Conclusion: Turmeric extract administration increased BDNF expression following repetitive traumatic brain injury

Paper Citation

in Harvard Style

Siahaan A., Japardi I. and Sadewo W. (2019). Turmeric Extract Administration Increases the Expression of Brain Derived Neurotropic Factor Following Repetitive Traumatic Brain Injuries.In Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI, ISBN 978-989-758-469-5, pages 15-18. DOI: 10.5220/0009841200150018

in Bibtex Style

@conference{ictromi19,
author={Andre Marolop Pangihutan Siahaan and Iskandar Japardi and Wismaji Sadewo},
title={Turmeric Extract Administration Increases the Expression of Brain Derived Neurotropic Factor Following Repetitive Traumatic Brain Injuries},
booktitle={Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,},
year={2019},
pages={15-18},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009841200150018},
isbn={978-989-758-469-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,
TI - Turmeric Extract Administration Increases the Expression of Brain Derived Neurotropic Factor Following Repetitive Traumatic Brain Injuries
SN - 978-989-758-469-5
AU - Siahaan A.
AU - Japardi I.
AU - Sadewo W.
PY - 2019
SP - 15
EP - 18
DO - 10.5220/0009841200150018