Effect of Lifestyle Modification Combined with Metformin on Serum Chemerin Concentration in Metabolic Syndrome Subjects

Brama Ihsan Sazli, Dharma Lindarto, Dian Anindita Lubis, Melati Silvani Nasution

2019

Abstract

Chemerin is an adipokine that plays an important role in inflammation development and insulin resistance by accommodating macrophage infiltration into adipose tissue. This study aimed to determine the effect of lifestyle modification with and without metformin on chemerin in metabolic syndrome. Forty-five metabolic syndrome subjects (IDF-2005) were randomly assigned to one of the two groups: placebo group (n=22) and metformin group (n=23). Both groups underwent a 12-week lifestyle modification (diet and moderate aerobic-exercise). Only 40 participants (placebo group n=20 and metformin group n=20) completed the survey whereas 5 participants dropped out of the study. After their lifestyle was modified, body weight, body mass index, waist circumference, and chemerin decreased significantly (P<0.001) in both groups. Moreover, there was a significant difference between both groups in body weight, BMI, and WC (P<0.05) but not for chemerin. Thus, lifestyle modification with metformin improved BW, BMI, and WC on metabolic syndrome, and there were no significant differences in reduced chemerin between placebo and metformin groups. Further investigations should be done to establish the effect of lifestyle modification combined with metformin on chemerin after an extended follow-up period.

Paper Citation

in Harvard Style

Sazli B., Lindarto D., Lubis D. and Nasution M. (2019). Effect of Lifestyle Modification Combined with Metformin on Serum Chemerin Concentration in Metabolic Syndrome Subjects.In Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI, ISBN 978-989-758-469-5, pages 38-43. DOI: 10.5220/0009855700380043

in Bibtex Style

@conference{ictromi19,
author={Brama Ihsan Sazli and Dharma Lindarto and Dian Anindita Lubis and Melati Silvani Nasution},
title={Effect of Lifestyle Modification Combined with Metformin on Serum Chemerin Concentration in Metabolic Syndrome Subjects},
booktitle={Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,},
year={2019},
pages={38-43},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009855700380043},
isbn={978-989-758-469-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,
TI - Effect of Lifestyle Modification Combined with Metformin on Serum Chemerin Concentration in Metabolic Syndrome Subjects
SN - 978-989-758-469-5
AU - Sazli B.
AU - Lindarto D.
AU - Lubis D.
AU - Nasution M.
PY - 2019
SP - 38
EP - 43
DO - 10.5220/0009855700380043