Correlation between Adiponectin Receptor (AdipoR) with Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), Peroxisome Proliferator-Activated Receptor Gamma (PPAR-ϒ), and p38-mitogen-activated protein kinases (MAPK) in Type 2 Diabetic Rats Treated with Puguntano (Turanga feel-terrae Lour.) Leaves Extract

Dharma Lindarto, Melati Silvani Nasution, Santi Syafril, Awaluddin Saragih

2019

Abstract

Adiponectin has a role in regulating metabolic processes, anti-inflammation, and insulin sensitizers. This study aimed to examine the correlation between adiponectin receptor (AdipoR) with FPG, insulin, HOMA-IR, PPAR-ϒ, and p38MAPK in rats model of T2DM. A total of 48 Wistar rats aged 8-10 weeks with a weight of 180-200 grams were selected. The Wistar rats were induced into T2DM by feeding high-fat (HFD) diet and injecting small doses of streptozotocin (STZ) 30 mg/kg.bw. The Wistar rats were then divided randomly into 2 groups: control group (n=24) and treatment group (n=24). The treatment group was given puguntano leaves extract at a dose of 200 mg/kg. BW once daily for 10 days. After that, AdipoR, FPG, insulin, HOMA-IR, PPAR-ϒ, and p38MAPK levels were examined. FPG, insulin, and HOMA-IR levels were significantly lower, but p38MAPK and AdipoR levels were significantly higher in the treatment group than in the control group. In the group of all subjects, there was a significant correlation between AdipoR with FPG, insulin, HOMA-IR, PPAR-ϒ and p38MAPK (r=-0.536, p=0.000**, r=-0.416, p=0.003**; r=-0.478, p=0.001**; r=0.587, p=0.000**; respectively). There was a significant correlation between AdipoR with the characteristic of insulin resistance (HOMA-IR) and pathways of post-receptor insulin (PPAR-ϒ and p38MAPK).

Paper Citation

in Harvard Style

Lindarto D., Nasution M., Syafril S. and Saragih A. (2019). Correlation between Adiponectin Receptor (AdipoR) with Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), Peroxisome Proliferator-Activated Receptor Gamma (PPAR-ϒ), and p38-mitogen-activated protein kinases (MAPK) in Type 2 Diabetic Rats Treated with Puguntano (Turanga feel-terrae Lour.) Leaves Extract.In Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI, ISBN 978-989-758-469-5, pages 52-55. DOI: 10.5220/0009855900520055

in Bibtex Style

@conference{ictromi19,
author={Dharma Lindarto and Melati Silvani Nasution and Santi Syafril and Awaluddin Saragih},
title={Correlation between Adiponectin Receptor (AdipoR) with Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), Peroxisome Proliferator-Activated Receptor Gamma (PPAR-ϒ), and p38-mitogen-activated protein kinases (MAPK) in Type 2 Diabetic Rats Treated with Puguntano (Turanga feel-terrae Lour.) Leaves Extract},
booktitle={Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,},
year={2019},
pages={52-55},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009855900520055},
isbn={978-989-758-469-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,
TI - Correlation between Adiponectin Receptor (AdipoR) with Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), Peroxisome Proliferator-Activated Receptor Gamma (PPAR-ϒ), and p38-mitogen-activated protein kinases (MAPK) in Type 2 Diabetic Rats Treated with Puguntano (Turanga feel-terrae Lour.) Leaves Extract
SN - 978-989-758-469-5
AU - Lindarto D.
AU - Nasution M.
AU - Syafril S.
AU - Saragih A.
PY - 2019
SP - 52
EP - 55
DO - 10.5220/0009855900520055