The Antidiabetic and Antioxidant Activities of Hydrolyzed Virgin Coconut Oil in Streptozotocin-induced Diabetic Rats

Linda Margata, Jansen Silalahi, Urip Harahap, Dwi Suryanto, Denny Satria

2019

Abstract

The aim of this study was to examine the antidiabetic and antioxidant effect of enzymatically hydrolyzed virgin coconut oil (HVCO) in streptozotocin (STZ) induced rats. VCO was hydrolyzed enzymatically using lipase from Rhizomucor miehei (active on sn-1,3 position). Thirty male rats were induced with 40 mg/kg body weight (BW) STZ. Rats with blood glucose level ≥ 250 mg/dl were divided into six groups which were given with sodium carboxymethylcellulose (CMC Na) 0.5%, metformin 45 mg/kgBW, VCO (4 and 6 ml/kgBW) and HVCO (4 and 6 ml/kgBW). Blood glucose, Haemoglobin A1c (HbA1c), superoxide dismutase (SOD), soluble receptor advanced glycosylation end-product (sRAGE) levels, and immunihistochemistry assay on pancreas were analyzed after 30 days of treatment. It is shown that HVCO 4 ml/kgBW and metformin were not significantly different in lowering blood glucose level. Blood glucose level in groups treated with HVCO 4 ml/kgBW and metformin were 409.2 and 364.40 mg/dl. HVCO also lowered HbA1c and sRAGE levels (55.50 ng/ml and 148.40 pg/ml, respectively), while increased SOD level (76.96 pg/ml). Insulin expression of rats treated with 4 ml/kgBW HVCO and metformin also did not differ significantly which were 11.40% and 11.70%, respectively. HVCO exerted higher antidiabetic and antioxidant effects that VCO did.

Paper Citation

in Harvard Style

Margata L., Silalahi J., Harahap U., Suryanto D. and Satria D. (2019). The Antidiabetic and Antioxidant Activities of Hydrolyzed Virgin Coconut Oil in Streptozotocin-induced Diabetic Rats.In Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI, ISBN 978-989-758-469-5, pages 152-159. DOI: 10.5220/0009862301520159

in Bibtex Style

@conference{ictromi19,
author={Linda Margata and Jansen Silalahi and Urip Harahap and Dwi Suryanto and Denny Satria},
title={The Antidiabetic and Antioxidant Activities of Hydrolyzed Virgin Coconut Oil in Streptozotocin-induced Diabetic Rats},
booktitle={Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,},
year={2019},
pages={152-159},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009862301520159},
isbn={978-989-758-469-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,
TI - The Antidiabetic and Antioxidant Activities of Hydrolyzed Virgin Coconut Oil in Streptozotocin-induced Diabetic Rats
SN - 978-989-758-469-5
AU - Margata L.
AU - Silalahi J.
AU - Harahap U.
AU - Suryanto D.
AU - Satria D.
PY - 2019
SP - 152
EP - 159
DO - 10.5220/0009862301520159