The Immunomodulatory Activity of Pirdot Leaf Extract (Sauraia Vulcani korth.) on the Immune System of Male Rats

Romauli Anna Teresia Marbun, Saadah Siregar, Ahmad Syukur Hasibuan, Jon Sinurat, Aminah Syarifuddin, Debi Dinha Octora, Vincentia Ade Rizky, Rahmad Gurusinga

2019

Abstract

Immune-mediated diseases are a significant problem in developing countries such as infectious diseases, cancer, and autoimmune disorders. The Sauraia vulcani Korth was studied has flavonoid compounds that have the potential as immunostimulants. The purpose of this study was to prove the immunomodulatory effect on phagocytic activity of phagocytic cells in male rats. The treatment group for carbon clearance test was divided into 6 groups with each consisting of 5 male rats including 0.5% CMC-Na group, Imboost® 32.5 mg / kgBB, ethanol extract of Sauraia vulcani Korth. doses of 50, 100, 200 and 400 mg / kgBB orally for 7 days and 8th day given carbon suspension i.v. Taking blood was carried out at a certain time and then measured the absorbance using a UV-Vis spectrophotometer. The rat's liver and spleen were taken and weighed.The results showed that the administration with doses of 50, 100, 200 and 400 mg / kgBB of ethanol extract of Sauraia vulcani Korthsignificantly increased phagocytic activity compared to 0.5% CMC-Na (p <0.05).This study proves that the ethanol extract of Sauraia vulcani Korth has an immunostimulatory effect on phagocytic activity which can be seen through phagocytic index parameters, stimulation index, and carbon clearance value.

Paper Citation

in Harvard Style

Marbun R., Siregar S., Hasibuan A., Sinurat J., Syarifuddin A., Octora D., Rizky V. and Gurusinga R. (2019). The Immunomodulatory Activity of Pirdot Leaf Extract (Sauraia Vulcani korth.) on the Immune System of Male Rats.In Proceedings of the International Conference on Health Informatics and Medical Application Technology - Volume 1: ICHIMAT, ISBN 978-989-758-460-2, pages 515-520. DOI: 10.5220/0009973805150520

in Bibtex Style

@conference{ichimat19,
author={Romauli Anna Teresia Marbun and Saadah Siregar and Ahmad Syukur Hasibuan and Jon Sinurat and Aminah Syarifuddin and Debi Dinha Octora and Vincentia Ade Rizky and Rahmad Gurusinga},
title={The Immunomodulatory Activity of Pirdot Leaf Extract (Sauraia Vulcani korth.) on the Immune System of Male Rats},
booktitle={Proceedings of the International Conference on Health Informatics and Medical Application Technology - Volume 1: ICHIMAT,},
year={2019},
pages={515-520},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009973805150520},
isbn={978-989-758-460-2},
}

in EndNote Style

TY - CONF

JO - Proceedings of the International Conference on Health Informatics and Medical Application Technology - Volume 1: ICHIMAT,
TI - The Immunomodulatory Activity of Pirdot Leaf Extract (Sauraia Vulcani korth.) on the Immune System of Male Rats
SN - 978-989-758-460-2
AU - Marbun R.
AU - Siregar S.
AU - Hasibuan A.
AU - Sinurat J.
AU - Syarifuddin A.
AU - Octora D.
AU - Rizky V.
AU - Gurusinga R.
PY - 2019
SP - 515
EP - 520
DO - 10.5220/0009973805150520