Effect of Jamblang (Syzygium cumini) Seed Extract on ALT and AST Levels in Isoniazid-induced Male Rats

Ahmad Syukur Hasibuan, Sri Melda Br. Bangun, Romauli Anna Teresia Marbun, Saadah Siregar, Aminah S., Debi Dinha Octora

2019

Abstract

Syzygium cumini or known in Indonesia as jamblang fruit which is contain gallic acid, elagic acid, corilagin, ellagitannin, isoquercetin, quercetin and other antioxidant. Elagic acid (EA) has a function as a free radical scavenger that can decrease liver function marking enzymes. Use of isonazide can cause side effects such as an increase in aminotransferase levels that occurs in 10% - 20% of patients several weeks after consumption. This study aims to determine the effect of Syzygium cumini seed extract in the ALT and AST values of male rats induced by isoniazid. The research subjects were 30 male white rats strain, weighing 150-200 grams and aged 2-3 months, which were divided into 5 groups. The negative control group was given aquades, while the positive control was given isoniazid as much as 40 mg on the 12th day until the 25th day. The treatment group was given Syzygium cumini seed extract with multilevel doses (20 mg / rat, 40 mg / rat, and 80 mg / rat) from day 8 to day 25 and isoniazid 40 mg on the 12th day, on the 12th, on 26thday ALT and AST levels were measured. Data were analyzed using One-Way Anova.The results of the One-Way Anova test in groups with various doses of extract of jamblang fruit extract (20 mg / rat, 40 mg / rat, and 80 mg / rat) showed significant results in reducing ALT and AST levels in isoniazid-induced rats, with p value <0.001 (α = 0.05).The result showed that administration of jamblang fruit extract can reduce ALT and AST levels of isoniazid-induced mice.

Paper Citation

in Harvard Style

Hasibuan A., Bangun S., Marbun R., Siregar S., S. A. and Octora D. (2019). Effect of Jamblang (Syzygium cumini) Seed Extract on ALT and AST Levels in Isoniazid-induced Male Rats.In Proceedings of the International Conference on Health Informatics and Medical Application Technology - Volume 1: ICHIMAT, ISBN 978-989-758-460-2, pages 543-550. DOI: 10.5220/0009974605430550

in Bibtex Style

@conference{ichimat19,
author={Ahmad Syukur Hasibuan and Sri Melda Br. Bangun and Romauli Anna Teresia Marbun and Saadah Siregar and Aminah S. and Debi Dinha Octora},
title={Effect of Jamblang (Syzygium cumini) Seed Extract on ALT and AST Levels in Isoniazid-induced Male Rats},
booktitle={Proceedings of the International Conference on Health Informatics and Medical Application Technology - Volume 1: ICHIMAT,},
year={2019},
pages={543-550},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009974605430550},
isbn={978-989-758-460-2},
}

in EndNote Style

TY - CONF

JO - Proceedings of the International Conference on Health Informatics and Medical Application Technology - Volume 1: ICHIMAT,
TI - Effect of Jamblang (Syzygium cumini) Seed Extract on ALT and AST Levels in Isoniazid-induced Male Rats
SN - 978-989-758-460-2
AU - Hasibuan A.
AU - Bangun S.
AU - Marbun R.
AU - Siregar S.
AU - S. A.
AU - Octora D.
PY - 2019
SP - 543
EP - 550
DO - 10.5220/0009974605430550