The Effectiveness of Clerodendrum Paniculatum. L against TNF- α in Rats Induced by S. Aureus

Mutiara Dwi Yanti, Prihantono, Dei Tiansa Barus, Putri Ayu Yessy Ariescha, Kholilah Lubis, Nurul Aini Siagian, Andayani Boang Manalu, Tetty Junita Purba

2019

Abstract

Staphylococus Aureus is one of the mastitis causes which causes inflammation due to elevated levels of TNF-α. This study aimed to analyze the anti-inflammatory activity of bag flower leaf (Clerodendrum Paniculatum L) on TNF-α level in rats that is induced by S. Aureus bacteria. This study used post test only control group design with 15 samples of Strain Sprague Dawley rats divided into 3 groups. K (-) group as normal control group, K (+) was induced by S. Aureus bacteria and the treatment group was administered by extract 150mg / kg BB then it is measured TNF-α levels by the enzyme-linked immunosorbent assay (ELISA) test method. Data were analyzed by using bivariate analysis namely one way ANOVA test. The results showed that Bag Flower Extract contains secondary metabolites in the form of flavonoids and tannins. Giving bag flower leaf extract (Clerodendrum Paniculatun L) at 150 mg / kg BB has anti-inflammatory action by reducing TNF-α levels in rate which is induced by staphylococcus aureus (P <0, 0). 05). It was concluded that the administration of bag flower leaf extract could reduce TNF-α cytokines due to S. Aureus bacteria. It is expected that future researchers will use human subjects to analyze TNF-α levels so that later bag flower leaves can be used as complementary therapies in mastitis treatment due to S. aureus bacteria.

Paper Citation

in Harvard Style

Yanti M., Prihantono., Barus D., Ariescha P., Lubis K., Siagian N., Manalu A. and Purba T. (2019). The Effectiveness of Clerodendrum Paniculatum. L against TNF- α in Rats Induced by S. Aureus.In Proceedings of the International Conference on Health Informatics and Medical Application Technology - Volume 1: ICHIMAT, ISBN 978-989-758-460-2, pages 596-603. DOI: 10.5220/0009979605960603

in Bibtex Style

@conference{ichimat19,
author={Mutiara Dwi Yanti and Prihantono and Dei Tiansa Barus and Putri Ayu Yessy Ariescha and Kholilah Lubis and Nurul Aini Siagian and Andayani Boang Manalu and Tetty Junita Purba},
title={The Effectiveness of Clerodendrum Paniculatum. L against TNF- α in Rats Induced by S. Aureus},
booktitle={Proceedings of the International Conference on Health Informatics and Medical Application Technology - Volume 1: ICHIMAT,},
year={2019},
pages={596-603},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009979605960603},
isbn={978-989-758-460-2},
}

in EndNote Style

TY - CONF

JO - Proceedings of the International Conference on Health Informatics and Medical Application Technology - Volume 1: ICHIMAT,
TI - The Effectiveness of Clerodendrum Paniculatum. L against TNF- α in Rats Induced by S. Aureus
SN - 978-989-758-460-2
AU - Yanti M.
AU - Prihantono.
AU - Barus D.
AU - Ariescha P.
AU - Lubis K.
AU - Siagian N.
AU - Manalu A.
AU - Purba T.
PY - 2019
SP - 596
EP - 603
DO - 10.5220/0009979605960603