Sulfasalazine as an Alternative Therapy for Generalized Pustular Psoriasis: Case Series and Review of Literature

Jhauharina Rizki Fadhilla, Eyleny Meisyah Fitri, Windy Keumala Budianti, Endi Novianto

2019

Abstract

Generalized pustular psoriasis (GPP), psoriasis of von Zumbusch, is infrequent and notoriously intractable skin disease, so as the treatments remain challenging. One of the treatments of choice for GPP is acitretin currently used by most countries. Unfortunately, our national health regulation prohibits acitretin and also other systemic retinoids. Thus, sulfasalazine has been given to our patients due topoor responseof cyclosporine and methotrexate (MTX) in previous treatment. We aimed to evaluate the efficacy of sulfasalazine in GPP. Three patients affected by GPP and unresponsive to previous treatment, received sulfasalazine started at the dosages of 1 gram/day. The dose was increased related to the response. We observed one patient with good result after 4 months administration. The other two stopped the treatment due to lack of response and severe digestive side effect. There were varied results of sulfasalazine therapy in GPP. It is known to acts against molecular mechanism by inducing neutrophil apoptosis which is abundant in GPP pathogenesis. Sulfasalazine has warranty of its availability so far, affordable, and shares efficacy as well.

Paper Citation

in Harvard Style

Fadhilla J., Fitri E., Budianti W. and Novianto E. (2019). Sulfasalazine as an Alternative Therapy for Generalized Pustular Psoriasis: Case Series and Review of Literature.In Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI, ISBN 978-989-758-469-5, pages 316-319. DOI: 10.5220/0009987703160319

in Bibtex Style

@conference{ictromi19,
author={Jhauharina Rizki Fadhilla and Eyleny Meisyah Fitri and Windy Keumala Budianti and Endi Novianto},
title={Sulfasalazine as an Alternative Therapy for Generalized Pustular Psoriasis: Case Series and Review of Literature},
booktitle={Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,},
year={2019},
pages={316-319},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009987703160319},
isbn={978-989-758-469-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,
TI - Sulfasalazine as an Alternative Therapy for Generalized Pustular Psoriasis: Case Series and Review of Literature
SN - 978-989-758-469-5
AU - Fadhilla J.
AU - Fitri E.
AU - Budianti W.
AU - Novianto E.
PY - 2019
SP - 316
EP - 319
DO - 10.5220/0009987703160319