Fixed Drug Eruption Due to Ambroxol

Puteri Wulandari, Kristo A. Nababan

2019

Abstract

Introduction:Fixed drug eruption (FDE) is a common cutaneous drug eruption characterized by the development of one or more annular, oval, erythematous and hyperpigmented patches as a result of systemic exposure to a drug. The lesion may recur at the same site and/or at the new sites with re-exposure to the offending drug(s). More than 100 drugs have been implicated in causing FDEs including ibuprofen, sulfonamides, naproxen and tetracyclines. There was only one case report fixed drug eruption due to Ambroxol in Japan. This is a second case report fixed drug eruption due to ambroxol. Case: A 37-years old Male came to Adam Malik Hospital Medan with the chief complaint an itchy, two similar violaceousmacular lesions on the left back of the hand anderythematosus macular lesion in his genital part. Three days ago, he was taking ambroxolthat he buy over-the-counter for treating his sore throats. Then the cutaneous lesion in the left back of the hand appeared about one day later followed by a cutaneous lesion in his genital part. He recalled a history of 2 similar episodes in the same location 1 year and 6 months ago due to the same medication (ambroxol) that resolved about 7-10 days without any treatment, leaving post-inflammatory hyperpigmentation. This patient was given an education to avoid the offending drug (ambroxol) because this has been the third times he was experienced. Then he was given cetirizine 10 mg once daily and topical desoximetasone cream applied on the lesion twice daily. Conclusion: There is an increased risk of cutaneous drug reactions with expectorants containing ambroxol. We must increase awarenessof fixed drug reaction cases due to the medications that are often used freely especially an over-the-counter medication.

Paper Citation

in Harvard Style

Wulandari P. and Nababan K. (2019). Fixed Drug Eruption Due to Ambroxol.In Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI, ISBN 978-989-758-469-5, pages 416-419. DOI: 10.5220/0009990504160419

in Bibtex Style

@conference{ictromi19,
author={Puteri Wulandari and Kristo A. Nababan},
title={Fixed Drug Eruption Due to Ambroxol},
booktitle={Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,},
year={2019},
pages={416-419},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009990504160419},
isbn={978-989-758-469-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,
TI - Fixed Drug Eruption Due to Ambroxol
SN - 978-989-758-469-5
AU - Wulandari P.
AU - Nababan K.
PY - 2019
SP - 416
EP - 419
DO - 10.5220/0009990504160419