Association of Epstein Barr Virus Infection to Prognosis Factors of Invasive Breast Cancer in Semarang Kariadi General Hospital Population

Wasisto Dwi Yudisaputro, Djoko Handojo, Yan Wisnu Prajoko, Dik Puspasari

2020

Abstract

Breast cancer is the most common malignant disease in female. In addition to internal factors, external factors such as viral infections are thought to have a role in the carcinogenesis process of breast cancer. In the case of nasopharyngeal cancer, Epstein-Barr Virus (EBV) has been shown to be able to activate several signaling pathways so that cancer cells become more aggressive and have a worse prognosis. This study aims to determine the relationship of the detection status of EBV DNA with the prognosis factor of breast cancer. The research design used in this study was analytic observational with a cross-sectional approach, with 71 paraffin block samples from the Anatomical Pathology Laboratory of Kariadi General Hospital who obtained from mastectomy or Breast Conserving Surgery. Samples was examined using PCR to detect EBV DNA in tumor cells. age of breast cancer cases ranged from 23 to 78 years with median age of 52 years. From 71 samples, there were 28 positive samples (39.4%) of EBV DNA and 43 samples (60.6%) were negative. Significant results were obtained (p < 0.05) in the relationship between EBV infection and tumor size (p = 0.002), axillary lymph node metastasis (p = 0.001), and lymphovascular invasion (p = 0.001). Our research could find a significant statistical association in the status of axillary lymph nodes, lymphovascular invasion status and tumor size in breast cancer samples infected by EBV and those not infected by EBV.

Paper Citation

in Harvard Style

Yudisaputro W., Handojo D., Prajoko Y. and Puspasari D. (2020). Association of Epstein Barr Virus Infection to Prognosis Factors of Invasive Breast Cancer in Semarang Kariadi General Hospital Population.In Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC, ISBN 978-989-758-499-2, pages 116-120. DOI: 10.5220/0010488701160120

in Bibtex Style

@conference{jimc20,
author={Wasisto Dwi Yudisaputro and Djoko Handojo and Yan Wisnu Prajoko and Dik Puspasari},
title={Association of Epstein Barr Virus Infection to Prognosis Factors of Invasive Breast Cancer in Semarang Kariadi General Hospital Population},
booktitle={Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,},
year={2020},
pages={116-120},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010488701160120},
isbn={978-989-758-499-2},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,
TI - Association of Epstein Barr Virus Infection to Prognosis Factors of Invasive Breast Cancer in Semarang Kariadi General Hospital Population
SN - 978-989-758-499-2
AU - Yudisaputro W.
AU - Handojo D.
AU - Prajoko Y.
AU - Puspasari D.
PY - 2020
SP - 116
EP - 120
DO - 10.5220/0010488701160120