DRD2 Gene Polymorphisms in Schizophrenia Patients

Zieske Maritska, Miranti Dwi Hartanti, Benediktus Wicaksono Widodo, Fitri, Bintang Arroyantri Prananjaya, Irsan Saleh, Nita Parisa

2020

Abstract

Schizophrenia is one of the most common mental health issues worldwide, affecting millions of people. Schizophrenia is a multifactorial condition with many risk factors, including genetics. Recent studies on the genetic factors underlying schizophrenia have focused on the genes such as the DRD2 gene that regulate dopamine function. The dopaminergic system plays a pivotal role as a modulator of affective and cognitive functions. Dopamine is a catecholamine that acts on the central nervous system and is inhibitory or excitatory, depending on the dopamine receptors activated. DRD2 is the main presynaptic receptor of the dopaminergic system. Polymorphisms of the DRD2 gene are known as risk factors for the occurrence of schizophrenia. Some of the known DRD2 gene polymorphisms that play a pivotal role in the incidence of schizophrenia are the Taq1A, -141C Ins/Del, and C957T polymorphisms. We summarize the effects of these polymorphisms on the risk of schizophrenia in different populations.

Paper Citation

in Harvard Style

Maritska Z., Hartanti M., Widodo B., Fitri., Prananjaya B., Saleh I. and Parisa N. (2020). DRD2 Gene Polymorphisms in Schizophrenia Patients.In Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC, ISBN 978-989-758-499-2, pages 139-142. DOI: 10.5220/0010489101390142

in Bibtex Style

@conference{jimc20,
author={Zieske Maritska and Miranti Dwi Hartanti and Benediktus Wicaksono Widodo and Fitri and Bintang Arroyantri Prananjaya and Irsan Saleh and Nita Parisa},
title={DRD2 Gene Polymorphisms in Schizophrenia Patients},
booktitle={Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,},
year={2020},
pages={139-142},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010489101390142},
isbn={978-989-758-499-2},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,
TI - DRD2 Gene Polymorphisms in Schizophrenia Patients
SN - 978-989-758-499-2
AU - Maritska Z.
AU - Hartanti M.
AU - Widodo B.
AU - Fitri.
AU - Prananjaya B.
AU - Saleh I.
AU - Parisa N.
PY - 2020
SP - 139
EP - 142
DO - 10.5220/0010489101390142