Comparison of Tear Interleukin-6 level, Conjunctival Inflammation, and Tear Film Function in Daily Conventional Hydrogel and Extended Silicone Hydrogel Contact Lens Wear

Tri Rahayu, Adisti, Weni Puspitasari, Umar Mardianto

2020

Abstract

Contact lenses were increasing use worldwide. Silicone hydrogel material was proposed to be safe for overnight Soft Contact Lens wear. This study aim to evaluate IL-6 levels, conjunctival inflammation, tear function and tear menisci parameters after overnight wear of silicone hydrogel Soft Contact Lens and compare with daily wear of hydrogel SCL. A randomized controlled trial carried out in myopia subjects, treated using daily hydrogel (Nefilcon-A) SCL in one eye, and overnight silicone hydrogel (Lotrafilcon-B) SCL in the fellow eye for 14 days. The slit lamp examination, NIBUT, Schirmer test, tear menisci measured with OCT, and tear sampling for IL-6 were performed before and after SCL wear. One hundred and for eyes from 52 subjects were included. The tear IL-6 significantly increases 6.37 pg/mL in Lotrafilcon-B and 4.46 pg/mL in Nefilcon-A. There were no significant conjunctival hyperemia changes in both groups (p=1.000) nor significant correlation of tear IL-6 levels and conjunctival hyperemia (p = 0.234). The NIBUT of both groups were decrease significantly (p=0.000). The Schirmer I were not significant changes after SCL wear. The tear meniscus height were not significantly decrease in both groups. The tear meniscus area were decrease significantly 1,181.5 μm2 in the the Lotrafilcon-B group and 1,795.0 μm2 in the Nelfilcon-A group. The tear meniscus volume were decrease 0.08 μL in the the Lotrafilcon-B 0.05 μL in the Nelfilcon-A group.The correlation between NIBUT, Schirmer I test and tear menisci parameter was not significant. Two weeks of daily hydrogel and weekly silicone hydrogel SCL wear comparably increases tear IL-6, did not increase conjunctival hyperemia, decreases NIBUT, tear menisci, without significant alterations in Schirmer.

Paper Citation

in Harvard Style

Rahayu T., Adisti., Puspitasari W. and Mardianto U. (2020). Comparison of Tear Interleukin-6 level, Conjunctival Inflammation, and Tear Film Function in Daily Conventional Hydrogel and Extended Silicone Hydrogel Contact Lens Wear.In Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC, ISBN 978-989-758-499-2, pages 155-163. DOI: 10.5220/0010489401550163

in Bibtex Style

@conference{jimc20,
author={Tri Rahayu and Adisti and Weni Puspitasari and Umar Mardianto},
title={Comparison of Tear Interleukin-6 level, Conjunctival Inflammation, and Tear Film Function in Daily Conventional Hydrogel and Extended Silicone Hydrogel Contact Lens Wear},
booktitle={Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,},
year={2020},
pages={155-163},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010489401550163},
isbn={978-989-758-499-2},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,
TI - Comparison of Tear Interleukin-6 level, Conjunctival Inflammation, and Tear Film Function in Daily Conventional Hydrogel and Extended Silicone Hydrogel Contact Lens Wear
SN - 978-989-758-499-2
AU - Rahayu T.
AU - Adisti.
AU - Puspitasari W.
AU - Mardianto U.
PY - 2020
SP - 155
EP - 163
DO - 10.5220/0010489401550163