Iron Status of Newborns in Maternal Inflammation Status Differences

Qodri Santosa, Alfi Muntafiah, Lantip Rujito

2020

Abstract

The human nervous system develops rapidly during the last pregnancy period and the beginning of human life, requiring much iron. Inflammation during pregnancy may interfere with materno-fetal iron transfer. The study aimed to compare the newborn iron status levels in maternal inflammation status differences. A crosssectional study was conducted with subjects of 84 clinically healthy newborns. We used C-reactive protein (CRP) and interleukin-6 (IL-6) as parameters of maternal inflammation. Maternal IL-6 was classified into two test groups based on quartile 1 (Q1) and quartile 2-4 (Q2-4), while CRP in the positive and negative groups. Statistical analysis used a t-test independent or Mann-Whitney test, with 95% confidence intervals and a significance limit at p <0.05. All newborns and their mothers were in healthy condition. Ferritin newborns' levels were higher in the positive than negative CRP group (450.6 ± 194.86 vs. 365.1 ± 212.91, with p = 0.02). Ferritin newborns were also higher in the maternal IL-6 Q2-4 group than in Q1, at levels 299.03 ± 154.98 vs. 492.35 ± 276.25, with p = 0.003. The study concluded that newborns' serum ferritin levels are higher in the maternal with CRP-positive and higher IL-6 groups. We should be careful in interpreting the elevated serum ferritin because it is also an acute-phase reactant.

Paper Citation

in Harvard Style

Santosa Q., Muntafiah A. and Rujito L. (2020). Iron Status of Newborns in Maternal Inflammation Status Differences.In Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC, ISBN 978-989-758-499-2, pages 194-201. DOI: 10.5220/0010490001940201

in Bibtex Style

@conference{jimc20,
author={Qodri Santosa and Alfi Muntafiah and Lantip Rujito},
title={Iron Status of Newborns in Maternal Inflammation Status Differences},
booktitle={Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,},
year={2020},
pages={194-201},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010490001940201},
isbn={978-989-758-499-2},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,
TI - Iron Status of Newborns in Maternal Inflammation Status Differences
SN - 978-989-758-499-2
AU - Santosa Q.
AU - Muntafiah A.
AU - Rujito L.
PY - 2020
SP - 194
EP - 201
DO - 10.5220/0010490001940201