The Effects of Administering Jicama Concentrate (Pachyrhizus erosus) and Kefir Grains as a Synbiotic Drink on Malondialdehyde and Superoxide Dismutase Levels in the Testicles of Hyperlipidemic Rats

Mohammad Alvian Subhakti, Miranti Dewi Pramaningtyas, Rafik Prabowo, Rokhima Lusiantari

2020

Abstract

Background: More than half of infertility prevalence come from men. There is a correlation between hyperlipidemia and male infertility. Malondialdehyde (MDA) and superoxide dismutase (SOD) are oxidative stress markers which indicate the testicular tissue damage caused by hyperlipidemia. The management of hyperlipidemia continues to develop to date, and synbiotics are potential for hyperlipidemia therapy. Objective: To examine the effects of jicama concentrate and kefir grains as a synbiotic drink on the levels of MDA and SOD of the testicles in hyperlipidemic rats. Methods: Twenty-five male Wistar rats were divided into 5 groups and given quail egg yolk for a month. The intervention group was given a synbiotic drink at a dose of 5ml/200grBW for a month with different combinations of jicama concentrate and kefir. The levels of MDA and SOD activity were checked after intervention. Result: The results showed that the mean MDA levels (nmol/ml) were 12.30 ± 0.28 (K +), 2.83 ± 0.27 (K-), 8.43 ± 0.38 (P1), 6.34 ± 0.29 (P2), and 4.49 ± 0.25 (P3) while the mean SOD activities (%) were 32.86 ± 6.75 (K+), 82.14 ± 7.57 (K-), 43.21 ± 5.56 (P1), 62.14 ± 7.40 (P2), 70.35 ± 4.82 (P3). There were significant differences in the MDA levels among all groups (p <0.01), whereas in SOD activities the differences were found among all groups except between K+ and P1, K- and P3, as well as P2 and P3 (p> 0.05). Conclusion: Jicama concentrate and kefir grain as a synbiotic drink significantly decrease MDA and increase SOD in testicular hyperlipidemic rats

Paper Citation

in Harvard Style

Subhakti M., Pramaningtyas M., Prabowo R. and Lusiantari R. (2020). The Effects of Administering Jicama Concentrate (Pachyrhizus erosus) and Kefir Grains as a Synbiotic Drink on Malondialdehyde and Superoxide Dismutase Levels in the Testicles of Hyperlipidemic Rats.In Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC, ISBN 978-989-758-499-2, pages 231-236. DOI: 10.5220/0010490502310236

in Bibtex Style

@conference{jimc20,
author={Mohammad Alvian Subhakti and Miranti Dewi Pramaningtyas and Rafik Prabowo and Rokhima Lusiantari},
title={The Effects of Administering Jicama Concentrate (Pachyrhizus erosus) and Kefir Grains as a Synbiotic Drink on Malondialdehyde and Superoxide Dismutase Levels in the Testicles of Hyperlipidemic Rats},
booktitle={Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,},
year={2020},
pages={231-236},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010490502310236},
isbn={978-989-758-499-2},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,
TI - The Effects of Administering Jicama Concentrate (Pachyrhizus erosus) and Kefir Grains as a Synbiotic Drink on Malondialdehyde and Superoxide Dismutase Levels in the Testicles of Hyperlipidemic Rats
SN - 978-989-758-499-2
AU - Subhakti M.
AU - Pramaningtyas M.
AU - Prabowo R.
AU - Lusiantari R.
PY - 2020
SP - 231
EP - 236
DO - 10.5220/0010490502310236