Unipolar Amplifier Enabling Measurement of Far-field Intra-cardiac Electromyogram for Blood Pump Control

Seraina Anne Dual, Seraina Anne Dual, Seraina Anne Dual, Dominic Jacob, Mirko Meboldt, Marianne Schmid Daners

2021

Abstract

Heart pumps are implanted as an alternative to heart transplantation in patients with heart failure. Future devices are expected to respond to the physiological need of each patient automatically. Physiological control algorithms have shown to be robust if based on the measurement of end-diastolic volume (EDV); but real-time measurements of EDV are not available. In theory, the EDV has been shown to correlate with the maximum depolarization amplitude (DA) of the intra-cardiac electromyogram (iEMG). In practice, this requires the unipolar measurement of an electric signal, which has not been attempted inside the heart. We herein present a custom-built unipolar amplifier, which we connected to a heart pump cannula prototype with four integrated off-the-shelf pacemaker electrodes. The recorded signals from the unipolar amplifier showed excellent agreement with the gold standard measurement of surface electrocardiogram (ECG) using a commercial ECG simulator and in-vivo data acquired in four pigs. We present recordings of unipolar iEMG from the cannula of a heart pump. The new unipolar amplifier makes it possible to measure the DA of the iEMG and therefore potentially provides a real-time EDV signal to heart pumps for physiological control in the future.

Paper Citation

in Harvard Style

Dual S., Jacob D., Meboldt M. and Schmid Daners M. (2021). Unipolar Amplifier Enabling Measurement of Far-field Intra-cardiac Electromyogram for Blood Pump Control. In Proceedings of the 14th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2021) - Volume 1: BIODEVICES; ISBN 978-989-758-490-9, SciTePress, pages 40-48. DOI: 10.5220/0010253800002865

in Bibtex Style

@conference{biodevices21,
author={Seraina Anne Dual and Dominic Jacob and Mirko Meboldt and Marianne Schmid Daners},
title={Unipolar Amplifier Enabling Measurement of Far-field Intra-cardiac Electromyogram for Blood Pump Control},
booktitle={Proceedings of the 14th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2021) - Volume 1: BIODEVICES},
year={2021},
pages={40-48},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010253800002865},
isbn={978-989-758-490-9},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 14th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2021) - Volume 1: BIODEVICES
TI - Unipolar Amplifier Enabling Measurement of Far-field Intra-cardiac Electromyogram for Blood Pump Control
SN - 978-989-758-490-9
AU - Dual S.
AU - Jacob D.
AU - Meboldt M.
AU - Schmid Daners M.
PY - 2021
SP - 40
EP - 48
DO - 10.5220/0010253800002865
PB - SciTePress