Dynamic Flow Behaviour of a Blood Analogue Fluid in Microchannels for Microcirculation Studies

I. Gonçalves, I. Gonçalves, J. M. Miranda, G. Coutinho, A. L. N. Moreira, A. S. Moita, D. Pinho, D. Pinho, D. Pinho, R. Lima, R. Lima, J. M. Montanaro, E. J. Veja, J. M. Montanaro, A. S. Moita

2021

Abstract

This study proposes a simple, stable and low cost 2-phase blood analogue fluid, which can mimic multiphase phenomena of real flow in microcirculation. This analogue fluid is mainly composed of Brij L4 surfactant suspended in pure water. The analogue fluid is compared with real blood, both in terms of thermophysical properties as well as in terms of its dynamic fluid flow behaviour, for different concentrations of the surfactant. The results on the particle size distribution confirm the reproducibility of the fluid preparation, as well as of its stability. The analogue fluid density is close to that of water, thus approaching the blood density. As for the rheology, the blood analogue fluid depicts a shear thinning behaviour, matching that of blood, except for very high Brij L4 concentrations. Fluid flow experiments show that the blood analogue can generate cell-free layers (CFL), with thickness close to that of real blood, which corroborates that the proposed analogue is able to mimic blood flow phenomena in microvessels. Increasing the surfactant concentration promotes the augmentation of the CFL’s, but also endorses agglomeration and clogging. Flow separation occurs also at the highest surfactant concentrations, which makes more difficult for the particles to follow the flow, so that flow field evaluation becomes more problematic.

Paper Citation

in Harvard Style

Gonçalves I., Varelas J., Coutinho G., Moita A., Moita A., Pinho D., Lima R., Miranda J., Veja E., Montanaro J. and Moreira A. (2021). Dynamic Flow Behaviour of a Blood Analogue Fluid in Microchannels for Microcirculation Studies. In Proceedings of the 14th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2021) - Volume 1: BIODEVICES; ISBN 978-989-758-490-9, SciTePress, pages 175-181. DOI: 10.5220/0010343900002865

in Bibtex Style

@conference{biodevices21,
author={I. Gonçalves and J. M. Varelas and G. Coutinho and A. S. Moita and A. L. N. Moita and D. Pinho and R. Lima and J. M. Miranda and E. J. Veja and J. M. Montanaro and A. S. Moreira},
title={Dynamic Flow Behaviour of a Blood Analogue Fluid in Microchannels for Microcirculation Studies},
booktitle={Proceedings of the 14th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2021) - Volume 1: BIODEVICES},
year={2021},
pages={175-181},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010343900002865},
isbn={978-989-758-490-9},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 14th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2021) - Volume 1: BIODEVICES
TI - Dynamic Flow Behaviour of a Blood Analogue Fluid in Microchannels for Microcirculation Studies
SN - 978-989-758-490-9
AU - Gonçalves I.
AU - Varelas J.
AU - Coutinho G.
AU - Moita A.
AU - Moita A.
AU - Pinho D.
AU - Lima R.
AU - Miranda J.
AU - Veja E.
AU - Montanaro J.
AU - Moreira A.
PY - 2021
SP - 175
EP - 181
DO - 10.5220/0010343900002865
PB - SciTePress