Substantially Improved Antioxidant Activity of Modified Polymeric Nanostructure Entrapping Curcumin

Deni Rahmat, Wahyu Widowati, Etik Mardliyati, Eny Kusrini, Abdi Septama, Yati Sumiyati, Mita Restinia, Sjaikhurrizal El Muttaqien, Cintani Wahyuni, Hanna Kusuma, Muhammad Aldi, Tri Handayani, Rizal Rizal, Rizal Rizal

2021

Abstract

BACKGROUND: Chronic and degenerative diseases due to free radicals cause oxidative stress in the body. The body requires natural antioxidants to cope with the negative effects of free radicals. Curcumin is a compound that has been shown to have pharmacological potential, such as antioxidant, anti-inflammatory, and anti-tumor properties. In recent years, the nanoparticle system for drug administration has become one of the most frequently studied methods of treating the disease. OBJECTIVE: This study aimed to formulate nanocurcumin (NC) to enhance its antioxidant activity. METHODS: The antioxidant activity of Curcumin and NC was evaluated using 2,2-diphenyl-1-pycrylhydrazyl (DPPH), 2,2'-azinobis-3-ethylbenzo-thiazoline-6-sulfonic acid (ABTS), H2O2, NO scavenging activities and ferric reducing antioxidant power (FRAP) assay. RESULTS: The results showed that the median Inhibitory Concentration (IC50) for DPPH, ABTS, H2O2, NO scavenging activities of NC was 0.68; 15.59; 24.98; 19.61 µg/mL, respectively. While the IC50 value for curcumin was 3.20; 18.54; 38.40; 24.94 µg/mL, respectively. The FRAP activity of NC and curcumin was 502.92 and 256.50 μM Fe(II)/μg, respectively, at the highest concentration of 50 µg/mL. CONCLUSION: The antioxidant activity of the NC was higher than that of curcumin alone. Thus, the nanoparticle system may enhance the antioxidant activity of curcumin.

Paper Citation

in Harvard Style

Rahmat D., Widowati W., Mardliyati E., Kusrini E., Septama A., Sumiyati Y., Restinia M., El Muttaqien S., Wahyuni C., Kusuma H., Aldi M., Handayani T. and Rizal R. (2021). Substantially Improved Antioxidant Activity of Modified Polymeric Nanostructure Entrapping Curcumin. In Proceedings of the 1st International Conference on Emerging Issues in Technology, Engineering and Science - Volume 1: ICE-TES, ISBN 978-989-758-601-9, pages 344-350. DOI: 10.5220/0010754000003113

in Bibtex Style

@conference{ice-tes21,
author={Deni Rahmat and Wahyu Widowati and Etik Mardliyati and Eny Kusrini and Abdi Septama and Yati Sumiyati and Mita Restinia and Sjaikhurrizal El Muttaqien and Cintani Wahyuni and Hanna Kusuma and Muhammad Aldi and Tri Handayani and Rizal Rizal},
title={Substantially Improved Antioxidant Activity of Modified Polymeric Nanostructure Entrapping Curcumin},
booktitle={Proceedings of the 1st International Conference on Emerging Issues in Technology, Engineering and Science - Volume 1: ICE-TES,},
year={2021},
pages={344-350},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010754000003113},
isbn={978-989-758-601-9},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Emerging Issues in Technology, Engineering and Science - Volume 1: ICE-TES,
TI - Substantially Improved Antioxidant Activity of Modified Polymeric Nanostructure Entrapping Curcumin
SN - 978-989-758-601-9
AU - Rahmat D.
AU - Widowati W.
AU - Mardliyati E.
AU - Kusrini E.
AU - Septama A.
AU - Sumiyati Y.
AU - Restinia M.
AU - El Muttaqien S.
AU - Wahyuni C.
AU - Kusuma H.
AU - Aldi M.
AU - Handayani T.
AU - Rizal R.
PY - 2021
SP - 344
EP - 350
DO - 10.5220/0010754000003113